Современные методы профилактики и лечения внутриматочных синехий (обзор литературы)


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Аннотация

Внутриматочные синехии, или синдром Ашермана, - многогранное заболевание, является одной из основных причин вторичного бесплодия. Частота диагностики данной патологии увеличивается в последнее время. Несмотря на широкое внедрение гистероскопического адгезиолизиса, лечение женщин с внутриматочными синехиями по-прежнему представляет собой большую проблему: частота рецидивов при тяжелой степени достигает 62,5%. Обзор литературы освещает современные возможности хирургического лечения, методы и средства профилактики рецидивов, а также наиболее перспективные исследования в области патогенеза и лечения синдрома Ашермана.

Об авторах

П М Хириева

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России

Email: dr.khirieva@rambler.ru
аспирантка гинекологического отд-ния ФГБУ НЦАГиП им. акад. В.И.Кулакова 117997, Россия, Москва, ул. Академика Опарина, д. 4

Л В Адамян

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России

Email: l_adamyan@oparina4.ru
академик РАН, д-р мед. наук, проф., зам. дир. по научной работе, рук. гинекологического отд-ния ФГБУ НЦАГиП им. акад. В.И.Кулакова 117997, Россия, Москва, ул. Академика Опарина, д. 4

С А Мартынов

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России

Email: s_martynov@oparina4.ru
д-р мед. наук, вед. науч. сотр. гинекологического отд-ния ФГБУ НЦАГиП им. акад. В.И.Кулакова 117997, Россия, Москва, ул. Академика Опарина, д. 4

Список литературы

  1. Адамян Л.В., Кулаков В.И. Эндоскопия в гинекологии. М.: Медицина, 2000
  2. Кулаков В.И., Савельева Г.М., Манухин И.Б. Гинекология. Национальное руководство. ГЭОТАР - Медиа, 2011.
  3. Руководство ВОЗ по стандартизированному обследованию и диагностике бесплодных супружеских пар. М.: МедПресс, 1997.
  4. Савельева Г.М., Бреусенко В.Г. Гинекология. М.: ГЭОТАР - Медиа, 2004.
  5. Сметник В.П., Тумилович Л.Г. Неоперативная гинекология. Руководство для врачей. М.: Медицинское информационное агентство, 1998.
  6. Levine R.U, Neuwirth R.S: Simultaneous laparoscopy and hysteroscopy for intrauterine adhesions. Obstet Gynecol 1973; 42: 441-5.
  7. Schenker J.G, Margalioth E.J. Intrauterine adhesions: an updated appraisal. Fertil Steril 1982; 37: 593-610.
  8. Reddy S, Rock J.A. Surgical management of complete obliteration of the endometrial cavity. Fertil Steril 1997; 67: 172-4.
  9. Al-Inany H. Intrauterine adhesions: an update. Acta Obstet Gynecol Scand 2001; 80: 986-93.
  10. Deans R, Abbott J. Review of intrauterine adhesions. J Minim Invasive Gynecol 2010; 17: 555-69.
  11. Sugimoto O. Diagnostic and therapeutic hysteroscopy for traumatic intrauterine adhesions. Am J Obstet Gynecol 1978; 131: 539-47.
  12. Valle R.F, Sciarra J.J. Intrauterine adhesions: hysteroscopic diagnosis classification, treatment, and reproductive outcome. Am J Obstet Gynecol 1988; 158: 1459-70.
  13. Chervenak F.A, Neuwirth R.S. Hysteroscopic resection of the uterine septum. Am J Obstet Gynecol 1981; 141: 351-3.
  14. De Cherney A, Polan M.L. Hysteroscopic management of intrauterine lesions and intractable uterine bleeding. Obstet Gynecol 1983; 61: 392-7.
  15. Capella-Allouc S, Morsad F, Rongieres-Bertrand C et al. Hysteroscopic treatment of severe Asherman’s syndrome and subsequent fertility. Hum Reprod 1999; 14: 1230-3.
  16. Yu D, Wong Y.M, Cheong Y et al. Asherman syndrome - one century later. Fertil Steril 2008; 89: 759-79.
  17. Zikopoulos K.A, Kolibianakis E.M, Platteau P et al. Live delivery rates in subfertile women with Asherman’s syndrome after hysteroscopic adhesiolysis using the resectoscope or the Versapoint system. Reprod Biomed Online 2004; 8: 720-5.
  18. Chapman R, Chapman K. The value of two stage laser treatment for severe Asherman’s syndrome. Br J Obstet Gynaecol 1996; 103: 1256-8.
  19. Newton J.R, Mac Kenzie W.E, Emens M.J, Jordan J.A. Division of uterine adhesions (Asherman’s syndrome) with the Nd-YAG laser. Br J Obstet Gynaecol 1989; 96: 102-4.
  20. Mc Comb P.F, Wagner B.L. Simplified therapy for Asherman’s syndrome. Fertil Steril 1997; 68: 1047-50.
  21. Protopapas A, Shushan A, Magos A. Myometrial scoring: a new technique for the management of severe Asherman’s syndrome. Fertil Steril 1998; 69: 860-4.
  22. Chen F.P, Soong Y.K, Hui Y.L. Successful treatment of severe uterine synechiae with transcervical resectoscopy combined with laminaria tent. Hum Reprod 1997; 12: 943-7.
  23. Valle R.F, Sciarra J.J. Intrauterine adhesions: hysteroscopic diagnosis classification, treatment, and reproductive outcome. Am J Obstet Gynecol 1988; 158: 1459-70.
  24. Kodaman P, Arici A. Intra - uterine adhesions and fertility outcome: how to optimize success? Curr Opin Obstet Gynecol 2007; 19: 207-14.
  25. Polishuk W.Z, Kohane S. Intrauterine adhesions: diagnosis and therapy. Obstet Gynecol Digest 1966; 8: 41.
  26. Ventolini G, Zhang M, Gruber J. Hysteroscopy in the evaluation of patients with recurrent pregnancy loss. Surg Endosc 2004; 18: 1782-4.
  27. Polishuk W.Z, Weinstein D. The Soichet intrauterine device in the treatment of intrauterine adhesions. Acta Eur Fertil 1976; 7: 215-8.
  28. Vesce F, Jorizzo G, Bianciotto A, Gotti G. Use of the copper intrauterine device in the management of secondary amenorrhea. Fertil Steril 2000; 73: 162-5.
  29. March C.M. Intrauterine adhesions. Obstet Gynecol Clin North Am 1995; 22: 491-505.
  30. Deans R, Abbott J. Review of intrauterine adhesions. J Minim Invasive Gynecol 2010; 17: 555-69.
  31. March C.M. Management of Asherman syndrome. Reprod Biomed Online 2011; 23: 63-76.
  32. Lin X, Wei M, Li T.C et al. A comparison of intrauterine balloon, intrauterine contraceptive device and hyaluronic acid gel in the prevention of adhesion reformation following hysteroscopic surgery for Asherman syndrome: a cohort study. Eur J Obstet Gynecol Reprod Biol 2013; 170: 512-6.
  33. Asherman J.G. Traumatic intrauterine adhesions. J Obstet Gynaecol Br Emp 1950; 57: 892-6.
  34. March C, Israel R, March A. Hysteroscopic management of intrauterine adhesions. Am J Obstet Gynecol 1978; 130: 653-7.
  35. Ismajovich B, Lidor A, Confino E, David M.P. Treatment of minimal and moderate intrauterine adhesions (Asherman syndrome). J Reprod Med 1985; 30: 769-72.
  36. Amer M.I, Abd-El-Maeboud K.H. Amnion graft following hysteroscopic lysis of intrauterine adhesions. J Obstet Gynaecol Res 2006; 32: 559-66.
  37. Orhue A.A, Aziken M.E, Igbefoh J.O. A comparison of two adjunctive treatments for intrauterine adhesions following lysis. Int J Gynaecol Obstet 2003; 82: 49-56.
  38. Pellicano M, Bramante S, Cirillo D et al. Effectiveness of autocrosslinked hyaluronic acid gel after laparoscopic myomectomy in infertile patients: a prospective, randomized, controlled study. Fertil Steril 2003; 80: 441-4.
  39. Guida M, Acunzo G, di Spiezio Sardo A et al. Effectiveness of auto - crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery: a prospective, randomized, controlled study. Hum Reprod 2004; 19: 1461-4.
  40. Metwally M, Watson A, Lilford R, Vandekerckhove P. Fluid and pharmacological agents for adhesion prevention after gynaecological surgery. Cochrane Database Syst Rev 2006; 19: CD001298.
  41. Reijnen M.M, Falk P, van Goor H, Holmdahl L. The antiadhesive agent sodium hyaluronate increases the proliferation rate of human peritoneal mesothelial cells. Fertil Steril 2000; 74: 146-51.
  42. Carta G, Cerrone L, Iovenitti P. Postoperative adhesion prevention in gynecologic surgery with hyaluronic acid. Clin Exp Obstet Gynecol 2004; 31: 39-41.
  43. Mais V, Cirronis M.G, Peiretti M et al. Efficacy of auto - crosslinked hyaluronan gel for adhesion prevention in laparoscopy and hysteroscopy: a systematic review and meta - analysis of randomized controlled trials. Eur J Obstet Gynecol Reprod Biol 2012; 160: 1-5.
  44. Tsapanos V.S, Stathopoulou L.P, Papathanassopoulou V.S, Tzingounis V.A. The role of Seprafilm bioresorbable membrane in the prevention and therapy of endometrial synechiae. J Biomed Mater Res 2002; 63: 10-4.
  45. Robertson D, Lefebvre G, Leyland N et al. Society of Obstetricians and Gynaecologists of Canada. SOGC clinical practice guidelines Adhesion prevention in gynaecological surgery. Int J Gynaecol Obstet 2010; 111: 193-7.
  46. Kim T, Ahn K.H, Choi D.S et al. A randomized, multi - center, clinical trial to assess the efficacy and safety of alginate carboxymethylcellulose hyaluronic acid compared to carboxymethylcellulose hyaluronic acid to prevent postoperative intrauterine adhesion. J Minim Invasive Gynecol 2012; 19: 731-6.
  47. Sugimoto O. Diagnostic and therapeutic hysteroscopy for traumatic intrauterine adhesions. Am J Obstet Gynecol 1978; 131: 539-47.
  48. Magos A. Hysteroscopic treatment of Asherman’s syndrome. Reprod Biomed Online 2002; 4 (Suppl. 3): 46-51.
  49. Myers E.M, Hurst B.S. Comprehensive management of severe Asherman syndrome and amenorrhea. Fertil Steril 2012; 97: 160-4.
  50. Sher G, Fisch J.D. Vaginal sildenafil (Viagra): a preliminary report of a novel method to improve uterine artery blood flow and endometrial development in patients undergoing IVF. Hum Reprod 2000; 15: 806-9.
  51. Takasaki A, Tamura H, Miwa I et al. Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium. Fertil Steril 2010; 93: 1851-8.
  52. Zinger M, Liu J.H, Thomas M.A. Successful use of vaginal sildenafil citrate in two infertility patients with Asherman’s syndrome. J Womens Health (Larchmt) 2006; 15: 442-4.
  53. Gargett C.E, Nguyen H.P, Ye L. Endometrial regeneration and endometrial stem/progenitor cells. Rev Endocr Metab Disord 2012; 13: 235-51.
  54. Nagori C.B, Panchal S.Y, Patel H. Endometrial regeneration using autologous adult stem cells followed by conception by in vitro fertilization in a patient of severe Asherman’s syndrome. J Hum Reprod Sci 2011; 4: 43-8.
  55. Santamaria Х, Cabanillas S, Cervelloґ I et al. Autologous cell therapy with CD1331 bone marrow - derived stem cells for refractory Asherman’s syndrome and endometrial atrophy: a pilot cohort study. Hum Reprod 2016; p. 1-10.
  56. Rein D.T, Schmidt T, Hess A.P et al. Hysteroscopic management of residual trophoblastic tissue is superior to ultrasound - guided curettage. J Minim Invasive Gynecol 2011; 18: 774-8.
  57. Tam W.H, Lau W.C, Cheung L.P et al. Intrauterine adhesions after conservative and surgical management of spontaneous abortion. J Am Assoc Gynecol Laparosc 2002; 9: 182-5.
  58. Kulier R, Kapp N, Glmezoglu A.M et al. Medical methods for first trimester abortion. Cochrane Database Syst Rev 2011; 9: CD002855.
  59. Neilson J.P, Gyte G.M, Hickey M et al. Medical treatments for incomplete miscarriage. Cochrane Database Syst Rev 2013; 28: 3. CD007223.
  60. Roy K.K, Baruah J, Sharma J.B et al. Reproductive outcome following hysteroscopic adhesiolysis in patients with infertility due to Asherman’s syndrome. Arch Gynecol Obstet 2010; 281: 355-61.
  61. Yu D, Li T.C, Xia E et al. Factors affecting reproductive outcome of hysteroscopic adhesiolysis for Asherman’s syndrome. Fertil Steril 2008; 89: 715-22.
  62. Farhi J, Bar-Hava I, Homburg R et al. Induced regeneration of endometrium following curettage for abortion: a comparative study. Hum Reprod 1993; 8: 1143-4.
  63. Tu Chun-Hua, Yang Xiao-Li, Qin Xiao-Yun et al. Management of intrauterine adhesions: A novel intrauterine device. Med Hypotheses 2013; 81: 394-6.
  64. Zhang Y, Lin X, Dai Y et al. Endometrial stem cells repair injured endometrium and induce angiogenesis via AKT and ERK pathways. Reproduction 2016. pii: REP-16-0286.
  65. Di Spiezio Sardo A, Calagna G, Scognamiglio M et al. Prevention of intrauterine post - surgical adhesions in hysteroscopy. A systematic review. Eur J Obstet Gynecol Reprod Biol 2016; 203: 182-92.
  66. Liu A.Z, Zhao H.G, Gao Y et al. Effectiveness of estrogen treatment before transcervical resection of adhesions on moderate and severe uterine adhesion patients. Gynecol Endocrinol 2016; p. 1-4.
  67. Lasmar R.B, Barrozo P.R, Parente R.C et al. Hysteroscopic evaluation in patients with in fertility. Rev Bras Ginecol Obstet 2010; 32: 393-7.
  68. Preutthipan S, Linasmita V. A prospective comparative study between hysterosalpingography and hysteroscopy in the detection of intra - uterine pathology in patients with infertility. J Obstet Gynaecol Res 2003; 29: 33-7.
  69. Xue X, Chen Q, Zhao G et al. The Overexpression of TGF-b and CCN2 in Intrauterine Adhesions Involves the NF-kB Signaling Pathway. PLoS ONE 2015; 10 (12): e0146159.doi: 10.1371/journal.pone.0146159
  70. Singh N, Mohanty S, Seth T et al. Autologous stem cell transplantation in refractory Asherman's syndrome: A novel cell based therapy. J Hum Reprod Sci 2014; 7: 93-8.

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