The role of genetic polymorphisms of the VEGF, COX2, MUC genes in the development of endometriosis-associated infertility


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Abstract

Endometriosis-associated infertility is an important medical and social problem, because affects up to 10% of women in the reproductive case, while even after treatment the pregnancy occurs in only one third of the patients. The etiology of endometriosis is still not precisely defined, despite ongoing research on this topic. In this review of the literature, we have tried to highlight the main work concerning the participation of immunological and genetic factors in the pathogenesis, and the role of vascular endothelial growth factor, mucins and cyclooxygenase-2 in more detail. Further studies of these pathogenetic manifestations of infertility in patients with endometriosis will make it possible to correct them in a timely manner, thereby increasing the chances of pregnancy.

About the authors

Natalia V Kulikova

Immanuel Kant Baltic Federal University; Saint Petersburg State University

Email: dockulikova@rambler.ru
Graduate Student Saint Petersburg, Russia

Inna I Kovalenko

Saint Petersburg State University

Email: innakov2010@yandex.ru
Cand. Sci. (Med.) Saint Petersburg, Russia

Dmitrii V Baibuz

Saint Petersburg State University

Email: baybooz@mail.ru
Deputy Director Saint Petersburg, Russia

Yanina A Lebedeva

Saint Petersburg State University

Email: yanina_simakova@mail.ru
obstetrician-gynecologist Saint Petersburg, Russia

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