Email this article The use of progesterone during pregnancy in women with epilepsy as an alternative to the correction of doses of anticonvulsants
- Authors: Tsallagova E.V.1, Generalov V.O.2, Sadykov T.R.2
-
Affiliations:
- Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
- Center of diagnostics and treatment for epilepsy “PlanetaMed”
- Issue: Vol 21, No 6 (2019)
- Pages: 12-15
- Section: LECTURE
- URL: https://journal-vniispk.ru/2079-5831/article/view/33945
- DOI: https://doi.org/10.26442/20795696.2019.6.190708
- ID: 33945
Cite item
Full Text
Abstract
Pregnancy is the most dangerous period in terms of interruption of even persistent and long-term remission. At the same time increasing the dose of anticonvulsant increases the risk of teratogenic effects.
Aim. to assess the possibility of using progesterone to prevent relapse of epileptic seizures during pregnancy.
Materials and methods. 38 pregnant patients with epilepsy with clinical remission before pregnancy, with relapse of epileptic seizures in I trimester of pregnancy, age 31.8±1.4 years. Dydrogesterone in a dose of 10 to 60 mg/day was prescribed after the relapse of remission. Anticonvulsant dosage was not changed. The blood progesterone concentration and EEG control was carried out.
Results. During pregnancy, the level of progesterone in the blood gradually increased from 77.8 nmol/l at 7–8 weeks of pregnancy to 521.1 nmol/l at 36–37 weeks of pregnancy, without exceeding the limits. EEG results did not deteriorate. None of the patients had seizures during pregnancy.
Conclusion. Progesterone therapy is an adequate and safe alternative to increasing the dose of anticonvulsants in case of recurrent seizures during pregnancy.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Elena V. Tsallagova
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Author for correspondence.
Email: gogayeva@mail.ru
Cand. Sci. (Med.)
Russian Federation, MoscowVasily O. Generalov
Center of diagnostics and treatment for epilepsy “PlanetaMed”
Email: planetamed@mail.ru
D. Sci. (Med.)
Russian Federation, MoscowTimur R. Sadykov
Center of diagnostics and treatment for epilepsy “PlanetaMed”
Email: veeg.russia@gmail.com
Sadykov
Russian Federation, MoscowReferences
- Battino D, Tomson T, Bonizzoni E. Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry. Epilepsia 2013; 54 (9): 1621–7.
- Li W, Hao N, Xiao Y. Clinical characteristics and pregnancy outcomes of new onset epilepsy during pregnancy. Medicine (Baltimore) 2019; 98 (27): e16156.
- Reddy DS. Pharmacology of catamenial epilepsy. Methods Find Exp Clin Pharmacol 2004; 26 (7): 547–61.
- Pennell PB. Antiepileptic drug: pharmacokinetics during pregnancy and lactation. Neurology 2003; 61 (Suppl. 2): 35–42.
- Веропотвелян П.Н., Веропотвелян Н.П., Журавлева С.А. и др. Эпилепсия у женщин, планирующих беременность. Здоровье женщины. 2015; 10: 56–64. [Veropotvelian P.N., Veropotvelian N.P., Zhuravleva S.A. et al. Epilepsiia u zhenshchin, planiruiushchikh beremennost’. Zdorov’e zhenshchiny. 2015; 10: 56–64 (in Russian).]
- Cagnetti C, Lattanzi S, Foschi N et al. Seizure course during pregnancy in catamenial epilepsy. Neurology 2014; 83 (4): 339–44.
- Valencia-Sanchez C, Crepeau AZ. Is adjunctive progesterone effective in reducing seizure frequency in patients with intractable catamenial epilepsy? Neurologist 2018; 23 (3): 108–12.
- Najafi M, Sadeghi MM. Progesterone therapy in women with intractable catamenial epilepsy. Adv Biomed Res 2013; 2: 8.
- Joshi S, Kapur J. Neurosteroid Regulation of GABA-A Receptors: A role in catamenial epilepsy. Brain Res 2019; 1703: 31–40.
- Тетруашвили Н.К., Агаджанова А.А. Ведение беременности у женщин с привычным выкидышем, обусловленным иммунологическими нарушениями. Consilium Medicum. 2010; 12 (6): 10–4. [Tetruashvili N.K., Agadzhanova A.A. Vedenie beremennosti u zhenshchin s privychnym vykidyshem, obuslovlennym immunologicheskimi narusheniiami. Consilium Medicum. 2010; 12 (6): 10–4 (in Russian).]
- Ших Е.В. Клинико-фармакологические аспекты применения дидрогестерона для сохранения беременности. Акушерство, гинекология и репродукция. 2010; 2: 6–9. [Shikh E.V. Kliniko-farmakologicheskie aspekty primeneniia didrogesterona dlia sokhraneniia beremennosti. Akusherstvo, ginekologiia i reproduktsiia. 2010; 2: 6–9 (in Russian).]
- Зыгмунт М., Сала Я. Прогестерон – новый взгляд на давно известное лекарство. Репродуктивна ендокринологiя. 2017; 1 (33): 17–25. [Zygmunt M., Sala Ia. Progesteron – novyi vzgliad na davno izvestnoe lekarstvo. Reproduktivna endokrinologiia. 2017; 1 (33): 17–25 (in Russian).]
Supplementary files
