The role of genetic hemostasis gene variants in the development of venous thrombosis in patients with atherosclerosis after COVID-19 infection
- Authors: Perevezentsev O.A1,2, Mamedov I.S.2, Burtsev D.V.1
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Affiliations:
- Rostov State Medical University
- Scientific and Practical Center for Specialized Medical Care for children named after V.F. Voyno-Yasenetsky Department of Health of the City of Mosсow
- Issue: Vol 15, No 2 (2025)
- Pages: 378-382
- Section: SHORT COMMUNICATIONS
- URL: https://journal-vniispk.ru/2220-7619/article/view/311326
- DOI: https://doi.org/10.15789/2220-7619-TRO-17816
- ID: 311326
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Abstract
Introduction. The new coronavirus infection (COVID-19) is one of the most important problems in modern medicine. One of the etiopathogenetic COVID-19 arms is presented by a disorder in the hemostasis system, which can be associated with emerging thrombosis of various localizations and altered vascular circulation in small vessels. But coagulation disorders can be pathogenetically associated with atherosclerotic processes in the vascular bed, which can be activated as early as at age of 35–40 years. Therefore, it is relevant to study the genetic factors between COVID-19 etiopathogenetic relation and thrombogenic and atherosclerotic pathological processes. Purpose of the study. To establish a relation between previous COVID-19 infection and risk of venous thrombosis caused by 8 genetic variants ((F2 20210G>A, F5 1691G>A, F7 10976G>A, F13 G>T, ITGA2 807C>T, ITGB3 1565 T>C, PAI-1 -675 5G>4G) in the coagulation system genes in patients with atherosclerosis. Materials and methods. The study included 172 patients aged 30 to 55 years with signs of atherogenic vascular lesions, who had episodes of venous thrombosis of various localizations within a year after clinically manifested COVID-19, confirmed by molecular genetic diagnostics of SARS-CoV-2, and 151 COVID-19 convalescent patients aged 30 to 54 years (comparison group), without episodes of venous thrombosis. Molecular genetic analysis of genetic variants of the hemostasis system genes was performed by real-time PCR with automated melting curve analysis. Results. According to the results of the association analysis of genetic variants with venous thrombosis in COVID-19 convalescent patients, a relation was established for 2 genetic variants, ITGA2 807C>T (TT OR = 5.59 (СI: 2.86–10.93, p < 0.001)) and ITGB3 1565 T>C (genotype CC, OR = 6.55 (СI: 2.23–19.22, p < 0.001)). Conclusion. Thus, we established an association between 2 genetic variants (ITGA2 807C>T and ITGB3 1565 T>C) and venous thrombosis in COVID-19 convalescent patients with atherosclerosis.
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##article.viewOnOriginalSite##About the authors
O. A Perevezentsev
Rostov State Medical University; Scientific and Practical Center for Specialized Medical Care for children named after V.F. Voyno-Yasenetsky Department of Health of the City of Mosсow
Author for correspondence.
Email: PZPO@mail.ru
PhD (Medicine), Associate Professor of the Department of Personalized and Translational Medicine, Rostov State Medical University; Laboratory Genetics Doctor, Laboratory of Clinical Diagnostic and Genetic Research, Scientific and Practical Center for Specialized Medical Care for children named after V.F. Voyno-Yasenetsky Department of Health of the City of Mosсow
Russian Federation, Rostov-on-Don; MosсowI. S. Mamedov
Scientific and Practical Center for Specialized Medical Care for children named after V.F. Voyno-Yasenetsky Department of Health of the City of Mosсow
Email: PZPO@mail.ru
PhD (Medicine), Leading Researcher
Russian Federation, MosсowD. V. Burtsev
Rostov State Medical University
Email: PZPO@mail.ru
DSc (Medicine), Professor, Head of the Department of Personalized and Translational Medicine
Russian Federation, Rostov-on-DonReferences
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