GENOTYPES OF EXTENSIVELY DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS: CLINICAL AND EPIDEMIOLOGICAL FEATURES OF PULMONARY TUBERCULOSIS
- 作者: Vasilieva N.R.1,2, Vyazovaya A.A.3, Zhuravlev V.Y.1, Solovieva N.S.1, Mokrousov I.V.3, Narvskaya O.V.1,3
-
隶属关系:
- Research Institute of Phthisiopulmonology
- North-Western State Medical University named after I.I. Mechnikov
- St. Petersburg Pasteur Institute
- 期: 卷 6, 编号 2 (2016)
- 页面: 179-183
- 栏目: SHORT COMMUNICATIONS
- URL: https://journal-vniispk.ru/2220-7619/article/view/118507
- DOI: https://doi.org/10.15789/2220-7619-2016-2-179-183
- ID: 118507
如何引用文章
全文:
详细
Here, we present clinical and epidemiological analysis of 85 Russian cases of pulmonary tuberculosis caused by an extensively drug-resistant M. tuberculosis strains. As defined by spoligotyping, M. tuberculosis strains belonged to the following genetic families: Beijing — 81.2%, which significantly exceeds the prevalence rate of this genotype (50%) in M. tuberculosis population across Russia; LAM — 14.1% and Ural — 4.7%. Among patients infected with Beijing strains prevailed alcohol and tobacco abused males; the main source of infection were family and penitentiary contacts. This group of patients has been characterized by a variety of clinical forms of lung disease with the prevalence of fibro-cavernous tuberculosis and a significant proportion of patients with interrupted treatment. Regardless of the M. tuberculosis strain genotype, the extensively drug-resistant pulmonary tuberculosis is characterized by severe course leading to the chronic disease with the relapses and poor response to anti-tuberculosis treatment, requiring repeated hospitalizations and surgical treatments.
作者简介
N. Vasilieva
Research Institute of Phthisiopulmonology;North-Western State Medical University named after I.I. Mechnikov
编辑信件的主要联系方式.
Email: sagievanr@gmail.com
Epidemiologist;
PhD Candidate, Epidemiology, Parasitology and Disinfectology Department,
191036, Russian Federation, St. Petersburg, Ligovsky av., 2-4
俄罗斯联邦A. Vyazovaya
St. Petersburg Pasteur Institute
Email: fake@neicon.ru
PhD (Biology), Senior Researcher, Laboratory of Molecular Microbiology,
St. Petersburg
俄罗斯联邦V. Zhuravlev
Research Institute of Phthisiopulmonology
Email: fake@neicon.ru
Head of the Department of the Laboratory Diagnostics,
St. Petersburg
俄罗斯联邦N. Solovieva
Research Institute of Phthisiopulmonology
Email: fake@neicon.ru
PhD (Medicine), Head of the Bacteriological Laboratory,
St. Petersburg
俄罗斯联邦I. Mokrousov
St. Petersburg Pasteur Institute
Email: fake@neicon.ru
PhD, MD (Biology), Head of the Laboratory of Molecular Microbiology,
St. Petersburg
俄罗斯联邦O. Narvskaya
Research Institute of Phthisiopulmonology;St. Petersburg Pasteur Institute
Email: fake@neicon.ru
PhD, MD (Medicine), Leading Researcher, Laboratory of Molecular Microbiology,
St. Petersburg
俄罗斯联邦参考
- Балабанова Я.М., Федорин И.М., Маломанова Н.А., Дробниевский Ф., Николаевский В.В., Сун Х., Машкова Ю.А., Симак Т.Г., Концевая И.С., Игнатьева О.А., Миронова С.А. Использование автоматизированной системы ВАСТЕС MGIT 960 в диагностике лекарственной устойчивости к резервным препаратам в г. Самаре // Туберкулез и болезни легких. 2009. Т. 86, № 10. С. 63–70. [Balabanova Ya.M., Fedorin I.M., Malomanova N.A., Drobnievski F., Nikolayevsky V.V., Sun H., Mashkova Yu.A., Simak T.G., Kontsevaya I.S., Ignatyeva O.A., Mironova S.A. Use of automated BACTEC MGIT 960 system in the diagnosis of resistance to reserve drugs agents in Samara. Tuberkulez i bolezni legkikh = Tuberculosis and Lung Diseases, 2009, vol. 86, no. 10, pp. 63–70. (In Russ.)]
- Вязовая А.А., Мокроусов И.В., Журавлев В.Ю., Соловьева Н.С., Оттен Т.Ф., Маничева О.А., Вишневский Б.И., Нарвская О.В. Молекулярная характеристика мультирезистентных штаммов Mycobacterium tuberculosis, выделенных на Северо-Западе России // Молекулярная генетика, микробиология и вирусология. 2016. № 1. С. 30–33. [Vyazovaya A.A., Mokrousov I.V., Zhuravlev V.Yu., Solovieva N.S., Otten T.F., Manicheva O.A., Vishnevsky B.I., Narvskaya O.V. Molecular characteristics of multidrug-resistant Mycobacterium tuberculosis strains in Northwest Russia. Molekulyarnaya genetika, mikrobiologiya i virusologiya = Molecular Genetics, Microbiology and Virology, 2016, no. 1, pp. 30–33. (In Russ.)]
- Гайда А.И., Никишова Е.И., Марьяндышев А.О. Регистрация и лечение больных туберкулезом с широкой лекарственной устойчивостью микобактерий туберкулеза в гражданском секторе Архангельской области // Туберкулез и болезни легких. 2013. Т. 90, № 12. С. 55–58. [Gaida A.I., Nikishova E.I., Maryandyshev A.O. The registration and treatment of patients with broad drug-resistant Mycobacterium tuberculosis in the civil sector of the Arkhangelsk region. Tuberkulez i bolezni legkikh = Tuberculosis and Lung Diseases, 2013, vol. 90, no. 12, pp. 55–58. (In Russ.)]
- Маркелов Ю.М. Клинико-эпидемиологические особенности туберкулеза с множественной лекарственной устойчивостью и причины его распространения в Карелии // Туберкулез и болезни легких. 2011. Т. 88, № 8. С. 11–17. [Markelov Yu.M. The clinical and epidemiological features of multidrug-resistant tuberculosis and reasons for its spread in Karelia. Tuberkulez i bolezni legkikh = Tuberculosis and Lung Diseases, 2011, vol. 88, no. 8, pp. 11–17. (In Russ.)]
- Эпидемическая ситуация по туберкулезу в России в 2014 году // Федеральный Центр мониторинга противодействия распространению туберкулеза [Epidemicheskaya situatsiya po tuberkulezu v Rossii v 2014 godu [The epidemic situation of tuberculosis in Russia in 2014]. Federal’nyi Tsentr monitoringa protivodeistviya rasprostraneniyu tuberkuleza [Federal Center for counteraction to monitor the spread of tuberculosis]. URL: http://www.mednet.ru/images/stories/files/CMT/tub_epidsituaciya.pdf (дата обращения: 15.01.2015)
- Balabanova Y., Nikolayevskyy V., Ignatyeva O., Kontsevaya I., Rutterford C.M., Shakhmistova A., Malomanova N., Chinkova Y., Mironova S., Fedorin I., Drobniewski F.A. Survival of civilian and prisoner drug-sensitive, multi- and extensive drug-resistant tuberculosis cohortsprospectively followed in Russia. PLoS One, 2011, vol. 6, no. 6, e:20531. doi: 10.1371/journal.pone.0020531
- Kamerbeek J., Schouls L., Kolk A., Van Agterveld M., Van Soolingen D., Kuijper S., Bunschoten A., Molhuizen H., Shaw R., Goyal M., Van Embden J. Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. J. Clin. Microbiol., 1997, vol. 35, no. 4, pp. 907–914.
- Mokrousov I., Vyazovaya A., Otten T., Zhuravlev V., Pavlova E., Tarashkevich L., Krishevich V., Vishnevsky B., Narvskaya O. Mycobacterium tuberculosis population in northwestern Russia: an update from Russian-EU/Latvian border region. PLoS One, 2012, vol. 7, no. 7, e:41318. doi: 10.1371/journal.pone.0041318
- Punga V.V., Jakubowiak W.M., Danilova I.D., Somova T.R., Volchenkov G.V., Kazionnyy B.Y., Nemtsova E.S., Kiryanova E.V., Kourbatova E.V. Prevalence of extensively drug-resistant tuberculosis in Vladimir and Orel regions, Russia. Int. J. Tuberc. Lung. Dis., 2009, vol. 13, no. 10, pp. 1309–1312.
- Van Embden J., Cave M., Crawford J., Dale J., Eisenach K., Gicquel B., Hermans P., Martin C., McAdam R., Shinnick T., Small P. Strain identification on Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology. J. Clin. Microbiol. 1993, vol. 31, no. 2, pp. 406–409.
- WHO. Global tuberculosis report 2014. WHO/HTM/TB/2014.08. WHO, Geneva, Switzerland, 2014. URL: apps.who.int/iris/bitstream/10665/137094/1/9789241564809_eng.pdf
- WHO. Multidrug and extensively drug-resistant TB (M/XDR-TB): 2010 global report on surveillance and response. WHO/HTM/TB/2010.3. WHO, Geneva, Switzerland, 2010. URL: http://apps.who.int/iris/bitstream/10665/44286/1/9789241599191_eng.pdf
补充文件
