Skin autofluorescence as part of the comprehensive assessment of clinical and metabolic status of patients with end-stage chronic kidney disease
- Authors: Konovalova D.Y.1, Lebedev P.A.1, Ushakova O.V.2, Potyakina E.E.2, Kornilin D.V.3, Grishanov V.N.3, Komarova M.V.3
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Affiliations:
- Samara State Medical University
- Samara Regional Clinical Hospital named after V.D. Seredavin
- Samara National Research University n.a. S.P. Korolev
- Issue: Vol 15, No 4 (2024)
- Pages: 329-343
- Section: Original study articles
- URL: https://journal-vniispk.ru/2221-7185/article/view/281639
- DOI: https://doi.org/10.17816/CS636904
- ID: 281639
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Abstract
BACKGROUND: Chronic kidney disease (CKD) is a common end-stage disease requiring kidney transplantation or dialysis, which main type is program hemodialysis (PHD). These high-cost technologies of renal replacement therapy have significantly improved over recent decades, but the quality of life remains low and mortality is still high, especially in patients receiving PHD. Currently, a number of parameters associated with poor prognosis have been identified, including skin autofluorescence (SAF), an affordable method to detect glycation end products (glycotoxins) in tissues, which claims to be an integral biomarker.
AIM: To assess relationship of SAF with clinical and metabolic status parameters in patients receiving renal replacement therapy.
MATERIALS AND METHODS: The study included 88 patients receiving PHD and 27 transplanted kidney recipients (TKR). The measurements were performed using the original SAF reader.
RESULTS: SAF was significantly higher in TKR and patients receiving PHD. A universal, pronounced relationship of SAF with age and smoking was found in the control, PHD, and TKR groups. Models of SAF determinants in each studied group were proposed. SAF was associated with malnutrition stages (by NRI; r=−0.39; p <0.001), the Charlson comorbidity index (r=0.60, p <0.0001), and inflammatory activity based on C-reactive protein in the PHD group (r=0.32, p <0.01).
CONCLUSION: Models of SAF determinants in each studied group were proposed. Furthermore, highly significant direct correlations with left ventricular hypertrophy and its negative ejection fraction were established in this group. These facts suggest that SAF is an integral parameter of cardiac remodeling and metabolic profile, primarily in patients receiving PHD, which promotes it as a prognostic parameter.
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##article.viewOnOriginalSite##About the authors
Darya Yu. Konovalova
Samara State Medical University
Email: snowflake0605@mail.ru
ORCID iD: 0009-0002-2964-2675
postgraduate student
Russian Federation, 89 Chapaevskaya street, 443099 SamaraPeter A. Lebedev
Samara State Medical University
Author for correspondence.
Email: palebedev@yahoo.com
ORCID iD: 0000-0003-3501-2354
SPIN-code: 8085-3904
MD, Dr. Sci. (Medicine), Professor
Russian Federation, 89 Chapaevskaya street, 443099 SamaraOlga V. Ushakova
Samara Regional Clinical Hospital named after V.D. Seredavin
Email: ushakova80@yandex.ru
ORCID iD: 0000-0002-2145-7216
MD, nephrologist
Russian Federation, 159, Tashkentskaya St., 443095 SamaraElena E. Potyakina
Samara Regional Clinical Hospital named after V.D. Seredavin
Email: pee1981@mail.ru
ORCID iD: 0000-0002-1382-1831
Russian Federation, 159, Tashkentskaya St., 443095 Samara
Dmitriy V. Kornilin
Samara National Research University n.a. S.P. Korolev
Email: kornilin@mail.ru
ORCID iD: 0000-0002-0694-4016
SPIN-code: 6245-0760
Cand. Sci. (Technology), Professor
Russian Federation, 34, Moscow highway, Samara 443086Vladimir N. Grishanov
Samara National Research University n.a. S.P. Korolev
Email: vladgrishanov@yandex.ru
ORCID iD: 0000-0002-6675-4396
SPIN-code: 1728-9104
Cand. Sci. (Technology), Associate Professor
Russian Federation, 34, Moscow highway, Samara 443086Marina V. Komarova
Samara National Research University n.a. S.P. Korolev
Email: marinakom@yandex.ru
ORCID iD: 0000-0001-6545-0035
SPIN-code: 4359-2715
Cand. Sci. (Biology), Associate Professor
Russian Federation, 34, Moscow highway, Samara 443086References
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