Investigation of triiodothyronine, thyroxine, and thyroid-stimulating hormone levels’ influence on atrial myocardial electrical instability in experimental hypothyroidism
- Authors: Rakhmatullov R.F.1, Dementeva R.E.1, Sheina A.E.1, Kondrateva K.P.1, Rakhmatullov F.K.1, Melnikova L.V.2
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Affiliations:
- Penza State University
- Russian Medical Academy of Continuous Professional Education
- Issue: Vol 16, No 2 (2025)
- Pages: 106-114
- Section: Original study articles
- URL: https://journal-vniispk.ru/2221-7185/article/view/309741
- DOI: https://doi.org/10.17816/CS676542
- EDN: https://elibrary.ru/GCWVYC
- ID: 309741
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Abstract
BACKGROUND: Identifying the association between thyroid dysfunction and the development of nonvalvular atrial fibrillation (AF) remains one of the complex and pressing issue in contemporary cardiology. To date, only a limited number of studies have examined the relationship between AF and the hypothalamic-pituitary-thyroid (HPT) axis, and the available findings are often contradictory. Few papers have explored the association between AF and HPT axis in experimental conditions.
AIM: The work aimed to evaluate the association between AF and the HPT axis in experimental models of hypothyroidism, euthyroidism, and thyrotoxicosis in rats.
METHODS: The study included 146 outbred rats. Group 1 comprised 42 rats with euthyroidism. Group 2 included 15 rats with overt thyrotoxicosis. Group 3 included 22 rats with subclinical thyrotoxicosis. Group 4 comprised 67 rats with euthyroid sick syndrome. The methods included electrocardiographic monitoring and measurement of thyroid hormone concentrations.
RESULTS: The frequency of AF paroxysms was found to depend on thyroid hormone levels: under euthyroid conditions, on thyroid-stimulating hormone (β = −0.250; p < 0.001) and thyroxine (β = 0.838; p = 0.012); in overt thyrotoxicosis, on thyroxine (β = 0.732; p = 0.00008) and triiodothyronine (β = 0.352; p = 0.043); and in subclinical thyrotoxicosis, on thyroxine (β = 2.1; p = 0.0002) and triiodothyronine (β = −0.970; p = 0.019). Threshold values of thyroid hormones were determined for euthyroid, subclinical, and overt thyrotoxic states.
CONCLUSION: A relationship between atrial fibrillation and thyroid functional status was established.
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##article.viewOnOriginalSite##About the authors
Ruslan F. Rakhmatullov
Penza State University
Email: capitalofgreat@icloud.com
ORCID iD: 0000-0002-2157-544X
SPIN-code: 5748-7530
MD, Cand. Sci. (Medicine), Associate Professor
Russian Federation, PenzaRenata E. Dementeva
Penza State University
Author for correspondence.
Email: rdementyeva@gmail.com
ORCID iD: 0000-0003-1497-5338
SPIN-code: 8461-0433
MD, Cand. Sci. (Medicine), Assistant Professor
Russian Federation, 40 Krasnaya st, Penza, 440026Alina E. Sheina
Penza State University
Email: alina_silukova@mail.ru
ORCID iD: 0000-0002-9373-7268
SPIN-code: 5785-5658
Russian Federation, Penza
Kristina P. Kondrateva
Penza State University
Email: free-tina@yandex.ru
ORCID iD: 0000-0002-8540-2054
SPIN-code: 4214-9987
Russian Federation, Penza
Fagim K. Rakhmatullov
Penza State University
Email: pgu-vb2004@mail.ru
ORCID iD: 0000-0002-2587-8325
SPIN-code: 3232-7425
MD, Dr. Sci. (Medicine), Professor
Russian Federation, PenzaLudmila V. Melnikova
Russian Medical Academy of Continuous Professional Education
Email: pgu-vb2004@mail.ru
ORCID iD: 0000-0003-4688-1272
SPIN-code: 6907-5327
MD, Dr. Sci. (Medicine)
Russian Federation, MoscowReferences
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