Correlation assessment of the relationship between selenium levels and some indicators of oxidative stress in the blood serum in patients with tick-borne rickettsiosis in the south of the khabarovsk territory
- Authors: Mokretsova E.V.1, Tomilka G.S.1, Kovalsky Y.G.1, Yakusheva N.Y.1, Shchupak A.Y.1, Maleev V.V.2
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Affiliations:
- Far Eastern State Medical University, Ministry of Health of Russia
- Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
- Issue: Vol 14, No 1 (2024)
- Pages: 71-76
- Section: Original Investigations
- URL: https://journal-vniispk.ru/2226-6976/article/view/267271
- DOI: https://doi.org/10.18565/epidem.2024.14.1.71–6
- ID: 267271
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Abstract
Objective. Evaluation of the relationship between selenium (Se) levels and oxidative status in patients with tick-borne rickettsiosis (TBR) caused by R. heilongjiangensis to understand the pathogenesis, assess the severity and possible prognosis of the disease.
Materials and methods. The Se levels and some chemiluminescence indicators in patients with a moderate form of TBR were analyzed.
Results. It was found that the mean blood serum Se level of the examined patients at the height of the disease was statistically significantly reduced, which was combined with a significant initiation of free radical oxidation processes and a sharp suppression of the mobilization of antioxidant antiradical defense. During the period of convalescence in patients with TBR, despite the extinction of the main clinical manifestations of the disease, the activity of free radical oxidation processes continued to increase. Correlation analysis revealed a reliable moderate negative relationship between the chemiluminescent parameters of short-lived reactive oxygen species and the blood serum Se level.
Conclusion. The data obtained indicate the conjugation of the processes of selenium and oxidative status. Se deficiency is reflected in a decrease in the activity of antioxidant antiradical defense.
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##article.viewOnOriginalSite##About the authors
Evgenia V. Mokretsova
Far Eastern State Medical University, Ministry of Health of Russia
Author for correspondence.
Email: bremer68@mail.ru
ORCID iD: 0000-0001-9492-2660
Cand. Med. Sci., Associate Professor, Department of Infectious Diseases and Epidemiology
Russian Federation, KhabarovskGennady S. Tomilka
Far Eastern State Medical University, Ministry of Health of Russia
Email: genntom@mail.fesmu.ru
ORCID iD: 0000-0002-8785-2147
Professor, MD, Head, Department of Infectious Diseases and Epidemiology
Russian Federation, KhabarovskYuri G. Kovalsky
Far Eastern State Medical University, Ministry of Health of Russia
Email: kovalyura@mail.ru
ORCID iD: 0000-0001-7433-6285
Professor, MD, Head, Department of Biological Chemistry and Clinical Laboratory Diagnostics
Russian Federation, KhabarovskNatalya Yu. Yakusheva
Far Eastern State Medical University, Ministry of Health of Russia
Email: whiteout@mail.ru
ORCID iD: 0000-0003-1561-5465
Cand. Pharm. Sci., Associate Professor, Department of Pharmacy and Pharmacology
Russian Federation, KhabarovskAlexander Yu. Shchupak
Far Eastern State Medical University, Ministry of Health of Russia
Email: schupakalex@mail.ru
ORCID iD: 0000-0001-6255-7638
Cand. Med. Sci., Associate Professor, Head, Department of Clinical Toxicology and Extreme Medicine
Russian Federation, KhabarovskViktor V. Maleev
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: maleyev@pcr.ru
ORCID iD: 0000-0001-5748-178X
Professor, Academician of the Russian Аcademy of Sciences, MD,, Advisor to the Director for Scientific Work
Russian Federation, MoscowReferences
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