Study of the Effect of Nonselective Organic Solvent Nature on the Self-Organization of Amphiphilic Block Copolymers of D,L-Lactide and Ethylene Oxide in Aqueous Solution

E. V. Kuznetsova; Кузнецова Е. В.; E. M. Shirokova; Широкова Е. М.; Yu. A. Puchkova; Пучкова Ю. А.; E. V. Yastremsky; Ястремский Е. В.; S. N. Chvalun; Чвалун С. Н.

doi:10.31857/S2308114723700279

Study of the Effect of Nonselective Organic Solvent Nature on the Self-Organization of Amphiphilic Block Copolymers of D,L-Lactide and Ethylene Oxide in Aqueous Solution

Authors: Kuznetsova E.V.¹, Shirokova E.M.¹, Puchkova Y.A.¹, Yastremsky E.V.², Chvalun S.N.¹^,3
Affiliations:
1. National Research Center “Kurchatov Institute”
2. Federal Research Center “Crystallography and Photonics,” Russian Academy of Sciences
3. Enikolopov Institute of Synthetic Polymer Materials, Russian Academy of Sciences
Issue: Vol 65, No 1 (2023)
Pages: 138-152
Section: Articles
URL: https://journal-vniispk.ru/2308-1147/article/view/139224
DOI: https://doi.org/10.31857/S2308114723700279
EDN: https://elibrary.ru/HSGETL
ID: 139224

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Abstract
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Abstract

The self-organization of biocompatible amphiphilic block copolymers of D,L-lactide and ethylene oxide with various hydrophobic poly(D,L-lactide) block length in aqueous media has been investigated. It has been shown that the nature of nonselective organic solvent has a considerable effect on the size, size polydispersity, and morphology of micelles of a block copolymer with a long poly(D,L-lactide) block. To elucidate the dependence of properties of block copolymer micelles on the common organic solvent type (acetone, tetrahydrofuran, N,N-dimethylformamide, and acetonitrile) various parameters of the used solvents have been estimated, and correlation between the Flory–Huggins coefficient and the surface tension between the hydrophobic block and the nonselective organic solvent and the parameters of micellar structures has been found.

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