Email this article β-Lactamase activity in the amniotic fluid
- Authors: Zanko A.S1, Semyonov D.M2
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Affiliations:
- Vitebsk Municipal Maternity Hospital N 2
- Vitebsk State Order Friendship of Peoples Medical University
- Issue: Vol 2, No 1 (2015)
- Pages: 18-21
- Section: Original study articles
- URL: https://journal-vniispk.ru/2313-8726/article/view/35259
- ID: 35259
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Abstract
Beta-lactamase activities were measured in the amniotic fluid and serum of pregnant women. The relationship between the parameters was analyzed and the clinical significance of biological resistance to beta-lactam antibiotics in this patient population was evaluated. A total of 40 women were distributed into groups by the following parameters: pregnancy (pregnant/nonpregnant), gestation term, and inflammatory process (present/not). Serum beta-lactamase activity was measured by the Biolactam test system. All patients exhibited beta-lactamase activities in the amniotic fluid and serum. High level of the blood beta-lactamase activity is a factor preventing effective therapy by beta-lactam antibiotics. Hence, evaluation of biological resistance to beta-lactam antibiotics before therapy prevents their unjustified prescription and improves the treatment efficiency.
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##article.viewOnOriginalSite##About the authors
A. S Zanko
Vitebsk Municipal Maternity Hospital N 2
Email: zas08021988@gmail.com
врач акушер-гинеколог Belarus, Vitebsk, 210017
D. M Semyonov
Vitebsk State Order Friendship of Peoples Medical UniversityBelarus, Vitebsk, 210023
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