Chronic endometritis and its impact on female reproductive function

Chronic endometritis is a local inflammatory disease characterized by the presence of plasma cells in endometrial stroma regardless of menstrual cycle phase. This diagnosis can be confirmed based only on morphological examination of endometrial biopsy what makes this diagnosis difficult to prove in clinically healthy patients who can not get pregnant or carry a child. According to statistics of the past five years, more than 30% women of reproductive age having repeated implantation failures in IVF cycles and recurrent miscarriages are diagnosed with chronic endometritis. Since this pathology is related to long persistence of microbial associations in uterine cavity, the gold standard of treatment is antibacterial therapy. It is elucidated that during a year after antibiotic treatment the rate of spontaneous pregnancy is increased in more than 60% women compared with women who do not receive treatment regarding chronic endometritis.