Email this article Medicines with active pharmaceutical ingredient diosmin: plaining of sample preparation
- Authors: Voronin A.V.1, Karpov A.V.1
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Affiliations:
- Samara State Medical University
- Issue: Vol 21, No 5-6 (2021)
- Pages: 9-15
- Section: Pharmacy
- URL: https://journal-vniispk.ru/2410-3764/article/view/105751
- DOI: https://doi.org/10.55531/2072-2354.2021.21.3.9-15
- ID: 105751
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Abstract
BACKGROUND: Most drugs in the form of tablets contain diosmin in the micronized flavonoid fraction. This is the reason for the low level recovery by means of solid-liquid extraction.
AIM: to determine optimal conditions for sample preparation of some drugs with active pharmaceutical ingredient diosmin with the use of mathematical experiment planning (Box-Behnken design).
MATERIALS AND METHODS: The study subjects were tablets Detralex® 1000 mg, Venarus® 900 mg, Detravenol® 1000 mg, Flebaven® 1000 mg, Phlebopha® 600 mg, Phlebodia 600 mg. Estimation of diosmin recovery by the method of solid-liquid extraction was made according to the algorithm of full factorial design with three level factors (Box-Behnken design).
RESULTS: The effect of some factors determining the extraction of diosmin from tablets Detralex® 1000 mg, Venarus® 900 mg, Detravenol® 1000 mg, Flebaven® 1000 mg, Phlebopha® 600 mg, Phlebodia 600 mg was estimated. Mathematical (regression) models of solid-liquid extraction of diosmin for each drug were developed. The most significant factor determining the diosmin recovery from drugs (tablet formulation) is the sodium hydroxide concentration. Other factors (acetonitrile concentration, extraction time, centrifugation time, addition of ammonium sulfate) fail to exert significant effect. The optimal value of sodium hydroxide concentration is 0.02 mol/l. Diosmin recovery doesn’t increase after the increase of the sodium hydroxide concentration above 0.02 mol/l.
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##article.viewOnOriginalSite##About the authors
Alexander V. Voronin
Samara State Medical University
Author for correspondence.
Email: a.v.voronin@samsmu.ru
Doctor of Pharmaceuticals Sciences, Associate Professor, Head of the Department of Chemistry, Institute of Pharmacy
Russian Federation, SamaraAlexander V. Karpov
Samara State Medical University
Email: karpov.sasha111@gmail.com
Postgraduate student, Department of Chemistry, Institute of Pharmacy
Russian Federation, SamaraReferences
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