FINDINGS OF GLYCEMIA MONITORING AFTER THE INSULIN THERAPY INITIATION IN PATIENTS WITH TYPE 2 DIABETES

Introduction. Initiation of insulin treatment is an important step in type 2 diabetes patients. Evaluation of carbohydrate level together with CGMS provides opportunity to estimate treatment efficacy. Aim of study is to evaluate CGMS results in type 2 diabetes patients after initiation of insulin treatment and 3 months later. Methods: CGMS was performed in 16 patients with T2DM within one week after hospital discharge. In 11 patients CGMS was repeated in 3 months. Patients requiring initiation of insulin treatment due to ineffective oral antidiabetic treatment were included. Those suffering from acute illnesses or conditions in previous 3 months were excluded from the study. All data are presented in Me[Q25;Q75] format. Results: The level of HbA1c decreased from 9,1[7,9;9,6]% to 7,1[6,8;7,6]% (p=0,006) months later. Decrease in moderate glycemia (9,2[8,0;9,5] mmol/l vs.7,9[7,3;9,1] mmol/l, p=0,03) and duration of glycemia more than 10 mmol/l (29[19;40]% vs. 16[8;29]%, р=0,04) by CGMS were also observed. CGMS results after hospital discharge did not correlate significantly with HbA1c 3 months later while there was strong and statistically significant correlation of CGMS results carried out 3 months later (R=0.89 p=0.0005 for mean glucose). No significant association was observed between HbA1c and glucose variability. Also there was no significant correlation between corresponding results of first and second CGMS.

type 2 diabetes mellitus, initiation of insulin, CGMS, glucose variability