GENETIC MARKERS CIMBINED WITH CLINICAL AND LABORATORY PARAMETERS ON THE PROGNOSIS OF COMPLICATIONS AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH ST-ELEVATION ACUTE CORONARY SYNDROME


Cite item

Full Text

Abstract

Aim: the aim of the study is to investigate the effect of genetic variants combined with clinical and laboratory parameters on the prognosis of complications after PCI in patients with ST-elevation and acute coronary syndrome. Material and methods. 171 patients, consequently hospitalized with ST-elevation ACS from 15.08.2011 to 02.11.2014 were observed. Patients with the recurrence of coronary insufficiency after PCI formed the group I (n = 43, 38 male patients, 88.4 %, average age 56.7 ± 10.2). Recurrent coronary angiography revealed stent restenosis of the infarct-related artery and repeated stenting was performed. Group II consisted of 128 patients (103 males, 80.5%) with an uncomplicated postoperative period, average age 56,3 ± 10,8). The results of genetic study by 7 polymorphic genetic variants, coronary angiography data, ECG, laboratory findings were analyzed. The results. Groups significantly differed in outcomes of PCI: recurrence of myocardial infarction was 9,3% and 0%, resp. (p=0,004), frequency of myocardial reinfarction was 21,0% and 0%, resp.(p<0,0001). The combination of alleles (4G/4G) of gene PAI-I + (G455A) of gene FI + (Т1565С) of gene I GPIII was defected in 9 patients (21,0%) of the group I and it was detected in 11 patients (8,6%) of group II when analized, resp.(p=0,03). The combination of alleles (G455A) of gene FI + (Т1565С) of gene I GPIII was detected in 10 patients (23,3%) of group I, this combination was met in 15 patients (11,7%) of group II. The combination of alleles (4G/4G) of gene PAI-I + (G455A) of gene FI + (Т1565С) of gene I GPIII + (G10976A) of gene VII was observed in 4 patients (9,3%) of group I and it was observed in 1 patient (0,8%) of group II, resp.(p=0,01). The combination of alleles (G455A) of gene FI + (Т1565С) of gene I GPIII + (G10976A) of gene VII was detected in 4 patients (9,3%) of group I and it was detected in 2 patients (1,6%) of group II, resp.(p=0,04). Conclusion. The combinations of genetic polymorphisms FI + PAI-I + GPIII, PAI-I + FI + GPIII + FVII, FI + GPIII, F1+ GPIII +FVII and FI + GPIII + FVII are associated with restenosis of stented infarct-related artery.

About the authors

V N KRUGLOV

Самарский государственный медицинский университет

Email: kruglov-v-n@mail.ru

A O RUBANENKO

Самарский государственный медицинский университет

Email: anatolii.rubanenko@gmail.com

References

  1. Хохлунов С.М., Дупляков Д.В., Тухбатова А.А. и др. Острый коронарный синдром с подьёмом сегмента ST - возможности госпитального регистра // Кардиология и сердечно-сосудистая хирургия. - 2010. - Т.3. - № 4. - С.27-31 (№ 1090).
  2. Хохлунов С.М., Павлова Т.В., Поляков В.П. и др. Распределение полиморфизмов генов, некоторых компонентов системы гемостаза у больных ишемической болезнью сердца // Кардиология. - 2009. - Т.49. - № 4. - С.9-12 (№ 1088).
  3. Ahmed W., Malik M., Saeed I. et al. Role of tissue plasminogen activator and plasminogen activator inhibitor in myocardial infarction // Mol. Biol. Rep. - 2011, Apr. - 38(4):8-2541.
  4. Behague I., Poirier O., Nicaud V. et al. Beta fibrinogen gene polymorphisms are associated with plasma fibrinogen and coronary artery disease in patients with myocardial infarction. The ECTIM Study. Etude Cas-Temoins sur l’Infarctus du Myocarde. Circulation. - 1996, Feb. - V.1. - 93(3):9-440.
  5. Boekholdt S.M., Bijsterveld N.R., Moons A.H. et al. Genetic variation in coagulation and fibrinolytic proteins and their relation with acute myocardial infarction: a systematic review // Circulation. - 2011. - 104: 3063-3068.
  6. Buysschaert I., Carruthers K.F., Dunbar D.R. et al. A variant at chromosome 9p21 is associated with recurrent myocardial infarction anf cardiac death after acute coronary syndrome: The GRACE Genetic Study // Eur. Heart J. - 2010. - V. 31. - Р. 1132-1141.
  7. Сaglivan C.E., Yuregir O.O., Balli M. at al. Plasminogen activator inhibitor-1 5G/5G genotype is associated with early spontaneous recanalization with acute ST-elevation myocardial infarction // Coron. Artery Dis. - 2013 May. - 24(3). - Р.196-200.
  8. Capros N., Barbacar N., Istrati V. et al. Aspects of the molecular-genetic profile in parients with heart disease // Rev. Med. Chir. Soc. Med. Nat. Iasi. - 2013, Jan-Mar. - 117(1). - Р.78-82.
  9. Сhung S.L., Chiou K.R., Charng M.J. 677TT polymorphism of methylentetrahydrofolate reductase in combination with low serum vitamin B12 is associated with coronary in-stent restenosis // Catheter Cardiovasc. Interv. - 2006 Mar. - 67(3): 55-349.
  10. Feng D., Lindpairtner K., Larson M.G. et al. Increased platelet aggregability associated with platelet GPIIIa PlA2 polymorphism: the Framingham Offspring Study // Arterioscler. Thromb. Vasc. Biol. -(1999). - 19. - P. 1142-1147.
  11. Floyd C.N., Mustafa A., Ferro F. The PIA1/A2 polymorphism of glycoprotein IIaas a risk factor for myocardial infarction: a meta-analyses // PLoS One. - 2014, Jul. - V. 2. - 9(7):e101518.
  12. Fox R.A., Dabbous O.H., Goldberg R.J. et al. Prediction of risk of dealth and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE) // BMJ. - 2006. - 333:1091.
  13. Gong L.L., Peng J.H., Han F.F. at al. Association of tissue plasminogen activator and plasminogen activator inhibitor polymorphism with myocardial infarction: a meta-analises. Tromb Res. 2012 Sep. - 130(3). - P.43-51.
  14. Juil K., Tybjaerg-Hansen A., Steffensen R. et al. Factor V Leiden: the Copenhagen City Heart Study and 2 2 meta-analyses // Blood. - 2002. - 100. - Р.3-10.
  15. Kluijtmans L.A., van den Heuvel L.P., Boers G.H. at al. Molecular genetic analyses in mild heperhomocysteinemia: a common mutation in the methylentetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease // Am J Hum Genet. - 1996, Jan. - 58(1). - Р.35-41.
  16. Laule M., Cascorbi I., Stangl N. et al. A1/A2 polymorphism of glycoprotein IIIa and association with excess procedural risk for coronary catheter intrerventions: a case-controlled study // Lancet. - 1999. - 353. - P.708-712.
  17. Maitland-van der Zee A.H., Peters B.J.M., Lynch A.I. et al. The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13) on the effectiveness of statins: the GenHAT study // Pharmacogenet Genomics. -2009. - 19. - Р.338-344.
  18. Mo X., Hao Y., Yang X. et al. Association between of polymorphisms in the coagulation factor VII gene and coronary heart desease risk in different ethnicities: a meta-analises // BMC Med Genet. - 2011 Aug. - 12. - 12:107.
  19. Monraats P.S., Rana J.S., Zwinderman A.H. et al. 455G/A polymorphism and preprocedural plasma levels of fibrinogen show no association with risk of clinical restenosis in patients with coronary stent placement // Tromb. Haemost. - 2005, Mar. - 93(3). - 9-564.
  20. Morrow D.A, Antman E.M, Charlesworth A. et al. TIMI risk score for ST-elevation myocardial infarction. A convenient, bedside, clinical score for risk assessment at presentation. An intravenous nPA for Treatment of infracting Myocardium II Trial substudy // Circulation. - 2000. - 102. - Р.2031-2037.
  21. Nikolopoulos G.K., Bagos P.G., Tsangaris I. at al. The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: a Mendelian randomization meta-analyses. Clin. Chem. Lab. Med. - 2014, Jul. - 52(7). -50-937.
  22. Pamukcu B., Oflaz H., Nisanci Y. The role of platelet glycoproteinin the high prevalence of in vitro aspirin resistance in patients with intracoronary stent restenosis // Am. Heart. J. - 2005 Apr. - 149(4). Р. 80-675.
  23. Reddy P., Babu S., Kuranakar V., et al. Angiotenzin-converting enzyme gene variant and its levels: risk factors for myocardial infarction ie Men a South Indian population // Singapurd J. - 2010. - 51(7):81-576.
  24. Szabo G.V. The role and importance of gene polymorphisms in the development of atherosclerosis // Interv. Med. Appl. Sci. - 2013 Mar. - 5(1). - Р.46-51.
  25. Water D.H., Schachinger V., Elsner M. et al. Platelet glycoprotein IIIa polymorphisms and Risk of coronary stent thrombosis // Lancet. - 1999. - 350. - P.1217-1219.
  26. Wu A.H., Tsongalis G.J. Correlation of polymorphisms to coagulation and biochemical risk factors for сardiovascular diseases // Am. J. Cardiol. - 2001. - 87. -Р.1366-1376.
  27. Ye. Z., Liu EH, Higgins JP et al. Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls // Lancet. - 2006. Feb. 25. - 367(9511):8-651.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2016 KRUGLOV V.N., RUBANENKO A.O.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).