Email this article Mexidol influenceon antimetastic activityof anticancer drugs
- Authors: Skopin P.I.1
-
Affiliations:
- Мордовский государственный университет им. Н.П. Огарева
- Issue: Vol 9, No 3-4 (2009)
- Pages: 104-106
- Section: Articles
- URL: https://journal-vniispk.ru/2410-3764/article/view/25258
- DOI: https://doi.org/10.17816/2072-2354.2009.0.3-4.104-106
- ID: 25258
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Abstract
The present study aimed to investigate the influence of combination of the synthetic
antioxidant mexidolum (3-oxy-6-metyl-2-etyl-piridin succinate) and antitumor drugs
- cyclophosphamide, 5-fluorouracil and rubomycine on cancer metastatic process. Studies
were performed on C57Bl mice which B16 melanoma had been implanted s.c. The volume
of primary tumor, quantity of lung surface metastases, ability to inhibit metastases were
determined. Mexidolum at a dose of 10 or 50 mg/kg body weight was injected i.m. daily
followed by tumor transplant for 25 days. Results showed that mexidolum significantly
increased antimetastatitic efficacy studied antitumor drugs.
antioxidant mexidolum (3-oxy-6-metyl-2-etyl-piridin succinate) and antitumor drugs
- cyclophosphamide, 5-fluorouracil and rubomycine on cancer metastatic process. Studies
were performed on C57Bl mice which B16 melanoma had been implanted s.c. The volume
of primary tumor, quantity of lung surface metastases, ability to inhibit metastases were
determined. Mexidolum at a dose of 10 or 50 mg/kg body weight was injected i.m. daily
followed by tumor transplant for 25 days. Results showed that mexidolum significantly
increased antimetastatitic efficacy studied antitumor drugs.
About the authors
Pavel Igorevich Skopin
Мордовский государственный университет им. Н.П. ОгареваКафедра онкологии с курсом лучевой диагностики и лучевой терапии, старший преподаватель.Научный консультант - профессор А.В. Зорькина; Мордовский государственный университет им. Н.П. Огарева
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