Markers of inflammation in the oral fluid of patients in need of dental prosthetics

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Abstract

Aim – to evaluate markers of the inflammatory process in the oral fluid of patients in need of orthopedic dental care.

Material and methods. A study of dental status was conducted, determining the DMFT (Decayed, Missing, Filled Teeth) index and the Green – Vermillion index in 40 individuals, 20 of whom were in the control group and 20 were patients requiring dental orthopedic care. Assessments were made during the initial consultation and after hygiene measures. Cytokine response indicators, viz. IL-1, IL-6, and immunoglobulin A, were determined using ELISA. CRP (C-reactive protein) levels were assessed using the Cobas Integra+ automatic biochemical analyzer (Roche). Statistical analysis included both parametric and non-parametric methods.

Results. When comparing the data from the control group and patients requiring dental prosthetics before sanitation, deviations were detected in CRP levels, more than 4 times higher, and IL-1, 158% higher. After sanitation and hygiene measures, the most pronounced changes were observed in CRP levels, with a 70.5% reduction.

Conclusions. Deviations in the levels of pro-inflammatory cytokines in oral fluid can serve as indicators of the risk of developing inflammatory processes in the body. The level of CRP in oral fluid is a reliable and rapidly responsive indicator of adequate anti-inflammatory therapy.

About the authors

Vladislav V. Kartashov

Samara State Medical University

Author for correspondence.
Email: stomkvv@gmail.com
ORCID iD: 0000-0002-8671-2898

MD, postgraduate student of the Department of Orthopedic Dentistry

Russian Federation, Samara

Aleksandr M. Nesterov

Samara State Medical University

Email: nesterov003@rambler.ru
ORCID iD: 0000-0001-8487-7392

MD, Dr. Sci. (Medicine), Professor, Head of the Department of Orthopedic Dentistry

Russian Federation, Samara

Inna A. Selezneva

Samara State Medical University

Email: Innola@mail.ru
ORCID iD: 0000-0001-6647-5330

MD, Dr. Sci. (Medicine), Associate Professor, Professor of the Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostics

Russian Federation, Samara

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