Email this article Combined laser treatment of bullous keratopathy: clinical results
- Authors: Drovnyak Y.A.1
-
Affiliations:
- Eye surgery clinic “MITSAR”
- Issue: Vol 25, No 1 (2025)
- Pages: 53-57
- Section: OPHTHALMOLOGY
- URL: https://journal-vniispk.ru/2410-3764/article/view/291088
- DOI: https://doi.org/10.35693/AVP646414
- ID: 291088
Cite item
Full Text
Abstract
Aim – to evaluate the efficacy and safety of combined laser treatment of bullous keratopathy.
Material and methods. The study included 83 patients with bullous keratopathy. Patients of group 1 (n = 56) underwent combined laser treatment including sequential corneal collagen crosslinking and phototherapeutic keratectomy. Patients of group 2 (n = 27) underwent isolated phototherapeutic keratectomy according to the standard technique. Follow-up was 1 year, within which patients underwent visometry, tonometry, biomicroscopy, as well as evaluation of corneal pain syndrome. Statistical analysis was performed using STATISTICA 12.0 software.
Results. Combined laser treatment was associated with earlier and more pronounced improvement of best corrected visual acuity (by 0.070 (0.055; 0.083) units by the end of the follow-up in group 1 vs. 0.030 (0.021; 0.035) units in group 2 (p < 0.001)), earlier corneal epithelialization (8.0 (8.0; 9.0) days vs. 11.0 (10.0; 11.0) days in groups 1 and 2, respectively (p < 0.001)), as well as earlier and more persistent corneal pain relief. Corneal pain recurrence was observed at 33.9% versus 59.3% of patients in groups 1 and 2, respectively (p = 0.029). Combined laser treatment contributed to the reduction of the disease progression rate (7.1% vs. 22.2% in groups 1 and 2, respectively (p = 0.048)).
Conclusion. The advantages of the proposed combined laser treatment of bullous keratopathy included earlier postoperative rehabilitation, more pronounced and persistent clinical results as well as reduction of disease progression rate.
Full Text
##article.viewOnOriginalSite##About the authors
Yana A. Drovnyak
Eye surgery clinic “MITSAR”
Author for correspondence.
Email: yanadrovnyak@gmail.com
ORCID iD: 0009-0009-0582-9372
deputy chief physician
Russian Federation, BlagoveshchenskReferences
- Filippova EO, Krivosheina OI. Manifestations of experimental bullous keratopathy and the effectiveness of cell therapy. Pathological Physiology and Experimental Therapy, Russian journal. 2020;64(1):23-30. [Филиппова Е.О., Кривошеина О.И. Особенности проявлений экспериментально индуцированной эндотелиально-эпителиальной дистрофии роговицы и эффективность клеточной терапии заболевания. Патологическая физиология и экспериментальная терапия. 2020;64(1):23-30]. DOI: 0031-2991.2020.01.23-30
- Denisko MS, Zhigalskaya TA, Krivosheina OI. Features of the local cytokine profile of patients with bullous keratopathy by using personalized therapy with cellular technologies. Acta Biomedica Scientifica. 2023;8(1):127-133. [Дениско М.С., Жигальская Т.А., Кривошеина О.И. Динамика локального цитокинового профиля при эндотелиально-эпителиальной дистрофии роговицы на фоне персонифицированной терапии с использованием клеточных технологий. Acta Biomedica Scientifica. 2023;8(1):127-133]. doi: 10.29413/ABS.2023-8.1.14
- Gurnani B, Kaur K. Pseudophakic Bullous Keratopathy. In: StatPearls. Treasure Island (FL): StatPearls Publishing; August 28, 2023.
- Trufanov SV, Salovarova EP. Corneal endothelial dysfunction: etiology, pathogenesis, and current treatment approaches. Russian Journal of Clinical Ophthalmology. 2019;19(2):116-119. [Труфанов С.В., Саловарова Е.П. Дисфункция эндотелиального слоя роговицы: этиопатогенез и современные подходы к лечению. Клиническая офтальмология. 2019;19(2):116-119]. doi: 10.32364/2311-7729-2019-19-2-116-119
- Filippova EO, Krivosheina OI. Methods of conservative and surgical treatment of epithelial-endothelial corneal dystrophy. Point of view. East – West. 2017;4(1):83-86. (In Russ.). [Филиппова Е.О., Кривошеина О.И. Методы консервативного и хирургического лечения эпителиально-эндотелиальной дистрофии роговицы. Точка зрения. Восток – Запад. 2017;4(1):83-86].
- Sharvadze NR, Shtilerman AL, Skachkov DP, Drovnyak YaA. Conservative methods of treatment of endothelial-epithelial dystrophy of cornea. Far East Medical Journal. 2020;2:97-101. [Шарвадзе Н.Р., Штилерман А.Л., Скачков Д.П., Дровняк Я.А. Консервативные методы лечения эндотелиально-эпителиальной дистрофии роговицы. Дальневосточный медицинский журнал. 2020;2:97-101]. doi: 10.35177/1994-5191-2020-2-96-100
- Marvanova LR. Еfficacy of Combined Treatment of Epithelial and Endothelial Corneal Dystrophy Using Corneal Crosslinking and Automated Posterior Lamellar Keratoplasty. Ophthalmology in Russia. 2019;16(1S):102-107. [Марванова Л.Р. Эффективность комбинированного лечения эпителиально-эндотелиальной дистрофии роговицы методом кросслинкинга роговицы и задней автоматизированной послойной кератопластики. Офтальмология. 2019;16(1S):102-107]. doi: 10.18008/1816-5095-2019-1S-102-107
- Pricopie S, Istrate S, Voinea L. Pseudophakic bullous keratopathy. Rom J Ophthalmol. 2017;61(2):90-94. doi: 10.22336/rjo.2017.17
- Rathi VM, Vyas SP, Sangwan VS. Phototherapeutic keratectomy. Indian Journal of Ophthalmology. 2012;60(1):5-14. doi: 10.4103/0301-4738.91335
- Angelo L, Boptom AG, McGhee C, Ziaei M. Corneal Crosslinking: Present and Future. Asia-Pacific Journal of Ophthalmology. 2022;11(5):441-452. doi: 10.1097/APO.0000000000000557
- Alessio G, L’Abbate M, Sborgia C, et al. Photorefractive Keratectomy Followed by Cross-linking Versus Cross-linking Alone for Management of Progressive Keratoconus: Two-Year Follow-up. Am J Ophthalmol. 2013;155(1):54-65.e1. doi: 10.1016/j.ajo.2012.07.004
- Pawiroranu S, Herani DN, Setyowati R, Mahayana IT. Outcomes of corneal collagen cross linking prior to photorefractive keratectomy in prekeratoconus. Ann Res Hosp. 2017;1:5. doi: 10.21037/arh.2017.04.05
Supplementary files
