Peculiarities of the course of rheumatoid arthritis in patients with thrombocytosis and comorbid conditions
- Authors: Mazurov V.I.1,2, Melnikov E.S.1,2, Morozova K.P.2, Evgrafova V.E.3
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Affiliations:
- I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia
- Clinical Rheumatology Hospital No. 25
- Inlab Genetics LLC
- Issue: Vol 9, No 1 (2023)
- Pages: 23-28
- Section: ORIGINAL STUDIES
- URL: https://journal-vniispk.ru/2412-4036/article/view/258792
- DOI: https://doi.org/10.18565/therapy.2023.1.23–28
- ID: 258792
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Abstract
Rheumatoid arthritis (RA) is a disease with a wide comorbid background, with the most common and socially significant being cardiovascular disease, which is the main cause of mortality.
Aim: to estimate and compare comorbidity profile in groups of RA patients with and without thrombocytosis.
Material and methods. The study enrolled 240 patients with RA, of whom 120 patients with normal thrombocytosis and 120 with thrombocytosis. Laboratory tests included assessment of the levels of RF, ACPA, ESR, CRP, ferritin, TPO, IL-6, soluble P-selectin. RA activity was determined by DAS28, instrumental examination consisted in determination of radiological stage of hand and foot lesions according to Steinbroecker, besides, the frequency of comorbid pathology was evaluated.
Results. The levels of ESR, CRP, IL-6, TPO-ferritin, RF and median values of DAS28 activity by ESR and CRP were significantly higher in subjects with RA and thrombocytosis compared to patients with normal level of platelets. There were also differences in the incidence of radiological stages I and III. In turn, in patients with thrombocytosis, the incidence of some comorbidities was significantly higher.
Conclusion. RA patients with thrombocytosis have higher clinical and laboratory activity as well as radiological progression of the disease in comparison with RA patients without thrombocytosis. These peculiarities of the course of RA require more intensive treatment. Besides, wide range of comorbid pathology is more frequent in the group of RA patients with thrombocytosis and this fact should be taken into consideration in real clinical practice.
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##article.viewOnOriginalSite##About the authors
Vadim I. Mazurov
I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia; Clinical Rheumatology Hospital No. 25
Author for correspondence.
Email: maz.nwgmu@yandex.ru
ORCID iD: 0000-0002-0797-2051
MD, professor, academician of RAS, Chief scientific consultant, director, head of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald, head of the Center for autoimmune diseases, Honored Worker of Science of the Russian Federation
Russian Federation, Saint Petersburg; 190068, Saint Petersburg, 30 Bol`shaya Pod`yacheskaya Str.Evgeny S. Melnikov
I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia; Clinical Rheumatology Hospital No. 25
Email: melnikovzhenya@mail.ru
ORCID iD: 0000-0002-8521-6542
postgraduate student at the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald, rheumatologist
Russian Federation, Saint Petersburg; 190068, Saint Petersburg, 30 Bol`shaya Pod`yacheskaya Str.Kira P. Morozova
Clinical Rheumatology Hospital No. 25
Email: kiramorozoba@mail.ru
ORCID iD: 0000-0002-4113-3104
rheumatologist
Russian Federation, 190068, Saint Petersburg, 30 Bol`shaya Pod`yacheskaya Str.Victoria E. Evgrafova
Inlab Genetics LLC
Email: Tinakonan@mail.ru
ORCID iD: 0000-0002-7050-6838
laboratory assistant
Russian Federation, 192019, Saint Petersburg, 37 Sedova Str.References
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