Prognostic value of serum biomarkers in case of chronic hepatitis C
- Authors: Tereshkin N.A.1, Makashova V.V.1, Ponezheva Z.B.1, Omarova K.G.1, Muzyka A.D.1, Gorelov A.V.1,2,3
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Affiliations:
- Central Research Institute of Epidemiology of Rospotrebnadzor
- I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
- Russian University of Medicine of the Ministry of Healthcare of Russia
- Issue: Vol 10, No 7 (2024)
- Pages: 28-34
- Section: ORIGINAL STUDIES
- URL: https://journal-vniispk.ru/2412-4036/article/view/267732
- DOI: https://doi.org/10.18565/therapy.2024.7.28-34
- ID: 267732
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Abstract
Despite the existence of direct-acting antiviral drugs, a significant proportion of patients with chronic hepatitis C (CHC) don’t receive necessary treatment. This leads to the development of liver cirrhosis (LC). Therefore, practical healthcare service is faced with the task of searching for early biomarkers of fibrogenesis.
The aim: to assess the prognostic value of biomarkers in the development of LC as a result of CHC.
Material and methods. 107 patients, including 66 with CHC and 41 with LC as a result of CHC were involved in the study. Osteopontin (OPN) and hepatocyte growth factor (HGF) were determined in the blood serum by enzyme immunoassay methodic. The stage of liver fibrosis (F) was detected using fibroelastometry on FibroScan medicine. To assess the diagnostic significance of fibrosis biomarkers in predicting the development of LC, the ROC curves analysis method was used.
Results. In patients with F0–F1, median of OPN concentration was 12.5 ng/ml, while in patients with F3–F4 it was 31.25 ng/ml (p = 0.004). In patients with F0–F1, median of HGF level was 441 pg/ml, while in patients with F3–F4 it was 1200 pg/ml (p < 0.001). Correlation of liver tissue stiffness indexes with OPN concentration showed a direct relationship of noticeable tightness, while with the HGF level it showed a direct relationship of high tightness (ρ = 0.716; p = 0.009). Threshold level of OPN in the cut-off point was 23 ng/ml, while for HGF it was 935 pg/ml. Sensitivity and specificity of OPN model were 88.2 and 82.8%, HGF – 75 and 88%, respectively.
Conclusion. With the development of liver cirrhosis, there is an increase in both OPN and HGF concentration. The level of OPN significantly correlates with the stage of fibrosis. A direct relationship of high tightness was fixed between the level of HGF and stiffness of the liver tissue. Sensitivity and specificity of biomarkers were estimated as excellent, since the areas under the curves were more than 0.8. Obtained results indicate the possibility of using OPN and HGF as biomarkers of progressive liver fibrosis and cirrhosis in the outcome of chronic hepatitis C.
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##article.viewOnOriginalSite##About the authors
Nikita A. Tereshkin
Central Research Institute of Epidemiology of Rospotrebnadzor
Author for correspondence.
Email: nteryoshkin@gmail.com
ORCID iD: 0009-0002-3541-4150
MD, postgraduate student
Russian Federation, MoscowVera V. Makashova
Central Research Institute of Epidemiology of Rospotrebnadzor
Email: veramakashova@yandex.ru
ORCID iD: 0000-0002-0982-3527
MD, Dr. Sci. (Medicine), professor, leading researcher at the Clinical Department of infectious pathology
Russian Federation, MoscowZhanna B. Ponezheva
Central Research Institute of Epidemiology of Rospotrebnadzor
Email: doktorim@mail.ru
ORCID iD: 0000-0002-6539-4878
MD, Dr. Sci. (Medicine), head of the Clinical Department of infectious pathology
Russian Federation, MoscowKhadizhat G. Omarova
Central Research Institute of Epidemiology of Rospotrebnadzor
Email: omarova71@inbox.ru
ORCID iD: 0000-0002-9682-2230
MD, PhD (Medicine), head of the Department of clinical research
Russian Federation, MoscowAnna D. Muzyka
Central Research Institute of Epidemiology of Rospotrebnadzor
Email: Amyzika@cmd.su
ORCID iD: 0000-0002-2269-2533
MD, PhD (Medicine), senior researcher at the Clinical Department of infectious pathology
Russian Federation, MoscowAlexander V. Gorelov
Central Research Institute of Epidemiology of Rospotrebnadzor; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University); Russian University of Medicine of the Ministry of Healthcare of Russia
Email: zdn@cmd.su
ORCID iD: 0000-0001-9257-0171
MD, academician of RAS, Dr. Sci. (Medicine), professor, deputy director for science, professor of the Department of childhood diseases, head of the Department of infectious diseases and epidemiology
Russian Federation, Moscow; Moscow; MoscowReferences
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