Immunological aspects of acute kidney injury in patients with liver cirrhosis
- Authors: Karzakova L.M.1, Ivanova A.L.1, Abyzov I.N.1, Sidorov I.A.1, Tarasova L.V.1, Odintsova A.V.1
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Affiliations:
- I.N. Ulyanov Chuvash State University of the Ministry of Education and Science of Russia Cheboksary
- Issue: Vol 10, No 2 (2024)
- Pages: 14-19
- Section: ORIGINAL STUDIES
- URL: https://journal-vniispk.ru/2412-4036/article/view/274510
- DOI: https://doi.org/10.18565/therapy.2024.2.14-19
- ID: 274510
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Abstract
Liver cirrhosis (LC) is often complicated by acute kidney injury (AKI), which is associated with high mortality.
The aim: to study the characteristics of the T- and B-immune systems in patients with LC complicated by AKI.
Material and methods. The study included a cohort of patients hospitalized for AKI that developed secondary to acute decompensation of liver cirrhosis. The comparison group consisted of patients with no renal dysfunction. Immunological testing included determination of the number of T lymphocytes, T helper/inducer cells, cytotoxic T lymphocytes, T lymphocytes expressing activation markers (HLA-DR antigen and interleukin 2 receptor), B lymphocytes, levels of IgM, IgG, IgA, circulating immune complexes (CIC), rheumatoid factor and antibodies to thyroid peroxidase (anti-TPO).
Results. In patients with AKI, an increase of IgG, IgA and CIC levels was observed comparatively to the group of healthy individuals. Patients of the compared group without AKI, had increased indexes of B cells, IgG, IgA, IgM and CIC. Patients with AKI had significantly higher levels of IgA, CIC, and anti-TPO, but lower IgM values relatively to the comparison group. As concerning T-system of immunity, an increase of the amount of T helper cells, activated cells and the value of the immunoregulatory index was fixed in the group of patients with the absence of AKI, in comparison with the group of healthy participants, while among patients with AKI only one index was increased – the level cytotoxic T lymphocytes in addition to immunoregulatory index decrease.
Conclusion. In contrast to the group of patients with cirrhosis without AKI, patients with such kind of complication showed a decrease in the immunoregulatory index in the presence of an increase in cytotoxic T cells and the absence of an increase in the number of activated T cells. Differences in humoral component of the immune response in patients with AKI were manifested in the absence of an increase in B-cells number and IgM level with a significant increase in levels of IgA, CIC and anti-TPO.
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##article.viewOnOriginalSite##About the authors
Luiza M. Karzakova
I.N. Ulyanov Chuvash State University of the Ministry of Education and Science of RussiaCheboksary
Author for correspondence.
Email: luizak58@mail.ru
ORCID iD: 0000-0002-5899-6352
MD, Dr. Sci. (Medicine), head of the Department of internal diseases
Russian Federation, 428015, Cheboksary, 15 Moskovsky AvenueAntonina L. Ivanova
I.N. Ulyanov Chuvash State University of the Ministry of Education and Science of RussiaCheboksary
Email: ial.antonina@yandex.ru
ORCID iD: 0000-0003-2054-7591
MD, assistant at the Department of hospital therapy
Russian Federation, 428015, Cheboksary, 15 Moskovsky AvenueIldar N. Abyzov
I.N. Ulyanov Chuvash State University of the Ministry of Education and Science of RussiaCheboksary
Email: ildarabyzov@gmail.com
MD, assistant at the Department of general surgery and oncology
Russian Federation, 428015, Cheboksary, 15 Moskovsky AvenueIvan A. Sidorov
I.N. Ulyanov Chuvash State University of the Ministry of Education and Science of RussiaCheboksary
Email: ivansv68@yandex.ru
ORCID iD: 0000-0003-3658-6579
MD, Dr. Sci. (Medicine) professor of the Department of internal diseases
Russian Federation, 428015, Cheboksary, 15 Moskovsky AvenueLarisa V. Tarasova
I.N. Ulyanov Chuvash State University of the Ministry of Education and Science of RussiaCheboksary
Email: tlarisagast18@mail.ru
ORCID iD: 0000-0003-1496-0689
MD, Dr. Sci. (Medicine), head of the Department of hospital therapy
Russian Federation, 428015, Cheboksary, 15 Moskovsky AvenueAnastasia V. Odintsova
I.N. Ulyanov Chuvash State University of the Ministry of Education and Science of RussiaCheboksary
Email: anastasia.od.99@mail.ru
ORCID iD: 0000-0001-7069-5029
resident of the Department of pediatrics and pediatric surgery
Russian Federation, 428015, Cheboksary, 15 Moskovsky AvenueReferences
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