Ideal marker of renal glomerular filtration rate: myth or reality?

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Abstract

Estimation of kidney function is important in modern diagnostics due to the increasing prevalence of renal diseases. According to the Global Burden of Disease, the number of new cases of chronic kidney disease in the world increased by 25% in 2012–2021. Early detection of renal damage can improve the prognosis of the disease in a particular patient, reduce mortality and the need for replacement therapy. A common method for renal function assessing is the analysis of glomerular filtration rate (GFR). It is considered to be an indicator of renal function, since it decreases with kidney damage. The most common marker for GFR assessment is creatinine. However, its level has significant individual variability and a blind range, and with a decrease in glomerular filtration of creatinine, tubular secretion increases. In this regard, the aim of the review was to analyze the literature data and data of clinical studies concerning renal function markers based on GFR, as well as their comparison based on the characteristics of the “ideal” marker.

About the authors

Safiya S. Nasyryanova

N.I. Lobachevsky National Research State University of Nizhny Novgorod

Email: safiya.nasyryanova@mail.ru
ORCID iD: 0009-0004-5900-7394

5th year student of the Faculty of general medicine of the Institute of clinical medicine

Russian Federation, Nizhny Novgorod

Larisa M. Obukhova

N.I. Lobachevsky National Research State University of Nizhny Novgorod

Author for correspondence.
Email: ObuhovaLM@yandex.ru
ORCID iD: 0000-0003-4064-9616
SPIN-code: 5202-2387
Scopus Author ID: 25947675500

Dr. Sci. (Biology), associate professor, professor of the Department of multidisciplinary clinical training of the Institute of clinical medicine

Russian Federation, Nizhny Novgorod

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