A fresh angle on nutritional support in chronic kidney disease: PLADO nutritional model

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Abstract

Chronic kidney disease (CKD) is accompanied by decreased kidney function and an increased risk of cardiovascular mortality. Properly selected diet can play a significant role in slowing the progression of that disease. Low-protein diet with a predominance of plant sources (PLADO – Plant-DOminant low-protein diet) is a promising dietary strategy in case of CKD. Combination of reduced protein intake and increased dietary fiber intake helps preserve kidney function, reduce systemic inflammation, optimize metabolic status, and reduce cardiovascular risk. Despite the proven benefits of PLADO food spectrum, there are several limitations to its use, so support from a dietitian is essential for comprehensive care and effective treatment outcomes for patients with CKD. Our review summarizes current evidence regarding the physiological basis of PLADO diet, its clinical efficacy, advantages, and potential disadvantages, with the aim of providing a comprehensive resource for clinical practice.

About the authors

Sofia O. Eliashevich

National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of Russia

Email: elsofol@yandex.ru
ORCID iD: 0000-0003-0143-0849
SPIN-code: 5267-5521
Scopus Author ID: 56646472600

MD, PhD (Medicine), dietarian, head of the Department for eating behavior study and correction

Russian Federation, Moscow

Alina P. Misharova

National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of Russia

Author for correspondence.
Email: gggalinamish@mail.ru
ORCID iD: 0000-0001-5816-3476
SPIN-code: 8980-3384
Scopus Author ID: 58571806700

MD, PhD (Medicine), junior researcher at the Department for eating behavior study and correction

Russian Federation, Moscow

Daniel D. Nunyes Araukho

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)

Email: dnunes@mail.ru
ORCID iD: 0000-0002-8346-9300

6th year student

Russian Federation, Moscow

Oksana M. Drapkina

National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of Russia

Email: drapkina@bk.ru
ORCID iD: 0000-0002-4453-8430
SPIN-code: 4456-1297
Scopus Author ID: 57208852308

MD, Dr. Sci. (Medicine), professor, academician of RAS, director

Russian Federation, Moscow

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