Osteoprotegerin gene polymorphisms in postmenopausal women with knee osteoarthritis

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Abstract

Aim – to investigate the associations of rs3134069, rs4355801 and rs3102735 polymorphisms in the TNFRSF11B gene with knee osteoarthritis in postmenopausal women.

Material and methods. 483 postmenopausal women were examined, including 157 patients with knee osteoarthritis. The remaining 326 women had no signs of joint disease and formed the control group. All examined women were tested using real-time polymerase chain reaction for single nucleotide polymorphisms rs3134069, rs4355801 and rs3102735 in the TNFRSF11B gene.

Results. It was found that genotypes distribution of polymorphisms rs3134069, rs4355801 and rs3102735 in the TNFRSF11B gene in the total group of examined women (n = 483) corresponded to the Hardy – Weinberg law (p > 0.05). The analysis of the polymorphic variants’ frequency in the TNFRSF11B gene revealed an increased frequency of AC or CC genotypes of rs3134069 polymorphism in patients with knee osteoarthritis (OR = 1.91; 95% CI: 1.10–3.32; p = 0.030). Also, the allele C frequency of the above-mentioned polymorphism was increased among patients with osteoarthritis (OR = 1.78; 95% CI: 1.06–2.99; p = 0.040). No association with knee osteoarthritis was found for two other studied polymorphisms in the TNFRSF11B gene – rs4355801 and rs3102735 (p > 0.05).

Conclusion. The increased frequency of genotypes AC or CC registration, as well as allele C of rs3134069 polymorphism in the TNFRSF11B gene in postmenopausal women with knee osteoarthritis indicates the important role of TNFRSF11B gene mutations in the osteoarthritis development and progression. Further research in this area is of great interest both for a deeper understanding of the disease pathogenesis and for the development of personalized approach in the prevention and treatment of knee osteoarthritis in postmenopausal women.

About the authors

Grigorii A. Ignatenko

M. Gorky Donetsk National Medical University

Email: prop-vnutr-medicina@dnmu.ru
ORCID iD: 0000-0003-3611-1186

PhD, Professor, corresponding member of the NAMS of Ukraine, Head of the Department of Propaedeutics of Internal Diseases

Russian Federation, Donetsk

Natalya A. Reznichenko

Medical Academy named after S.I. Georgievsky of Vernadsky Crimean Federal University

Email: professorreznichenko@mail.ru
ORCID iD: 0000-0003-3396-1046

PhD, Professor of the Department of Obstetrics and Gynecology No. 1

Russian Federation, Simferopol

Pavel N. Fedulichev

Medical Academy named after S.I. Georgievsky of Vernadsky Crimean Federal University

Email: pfedulichev@yandex.ru
ORCID iD: 0000-0002-5492-0270

PhD, Associate professor of the Department of Topographic Anatomy

Russian Federation, Simferopol

Eduard A. Maylyan

M. Gorky Donetsk National Medical University

Author for correspondence.
Email: maylyan.ea@yandex.com
ORCID iD: 0000-0003-2845-7750

PhD, Professor, Head of the Department of Microbiology, Virology, Immunology and Allergology

Russian Federation, Donetsk

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Copyright (c) 2024 Ignatenko G.A., Reznichenko N.A., Федуличев P.Н., Maylyan E.A.

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