Email this article Comparison of pharmacological activity of hawthorn fruits preparations
- Authors: Kurkin V.A.1, Zaitceva E.N.1, Avdeeva E.V.1, Stenyaeva V.V.1, Shaikhutdinov I.K.1, Zhdanova A.V.1
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Affiliations:
- Samara State Medical University
- Issue: Vol 5, No 2 (2020)
- Pages: 136-139
- Section: Pharmacology
- URL: https://journal-vniispk.ru/2500-1388/article/view/43804
- DOI: https://doi.org/10.35693/2500-1388-2020-5-2-136-139
- ID: 43804
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Abstract
Objectives – a comparative study of antidepressant activity and diuretic action of water and water-alcohol preparations of the fruits of Crataegus sanguinea Pall. and Crataegus submollis Sarg.
Materials and methods. The study covers the water and alcohol-water extracts from the fruits of hawthorn blood-red (Crataegus sanguinea Pall.) and Quebec hawthorn (Crataegus submollis Sarg.). The comparative study of the antidepressant activity and the diuretic action of the preparations was carried out on white mongrel rats of both sexes.
Results. The liquid extracts of fruits Crataegus sanguinea Pall. and Crataegus submollis Sarg. at a dose of 100 µl/kg revealed an antidepressant activity. Decoctions of Crataegus sanguinea Pall. and Crataegus submollis Sarg. at a dose of 100 µl/kg had a pronounced diuretic and saluretic activity. Pharmacotherapeutic effects of the studied preparations can be explained by the presence of flavonoids in them.
Conclusion. The preparations of the fruits of Crataegus sanguinea Pall. and Crataegus submollis Sarg. can be recommended as antidepressant and diuretic agents. The fruits of Crataegus submollis Sarg. are the promising medicinal plant raw materials.
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##article.viewOnOriginalSite##About the authors
Vladimir A. Kurkin
Samara State Medical University
Author for correspondence.
Email: Kurkinvladimir@yandex.ru
ORCID iD: 0000-0002-7513-9352
PhD, Professor, Head of the Department of pharmacognosy with botany and the basics of phytotherapy
Russian Federation, SamaraElena N. Zaitceva
Samara State Medical University
Email: Kurkinvladimir@yandex.ru
ORCID iD: 0000-0001-5689-2077
PhD, Associate Professor, Head of the Department of pharmacology n.a. Honoured Scientist Professor A.A. Lebedev
Russian Federation, SamaraElena V. Avdeeva
Samara State Medical University
Email: Kurkinvladimir@yandex.ru
ORCID iD: 0000-0003-3425-7157
PhD, Professor, Department of pharmacognosy with botany and the basics of phytotherapy
Russian Federation, SamaraViktoriya V. Stenyaeva
Samara State Medical University
Email: Kurkinvladimir@yandex.ru
ORCID iD: 0000-0003-0086-7213
PhD, Associate Professor, Department of pharmacognosy with botany and the basics of phytotherapy
Russian Federation, SamaraIlnur Kh. Shaikhutdinov
Samara State Medical University
Email: Kurkinvladimir@yandex.ru
ORCID iD: 0000-0001-8784-0464
postgraduate students of the Department of pharmacognosy with botany and the basics of phytotherapy
Russian Federation, SamaraAlina V. Zhdanova
Samara State Medical University
Email: Kurkinvladimir@yandex.ru
ORCID iD: 0000-0002-5881-1784
PhD, Associate Professor, Department of general, bioinorganic and bioorganic chemistry
SamaraReferences
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