Synthesis and structure-activity-relationships of indan acid derivatives as analgesic and anti-inflammatory agents

Abstract

Indan ring system, also known as indane or benzocyclopentane, is an important chemical feature associated with various biological activities. Among the drugs possessing an indan ring system, 1H-indene-3-acetic acid-5-fluoro-2-methyl-1-[4-(methylsulfinyl)-phenyl]methylene (Sulindac) and 6-chloro-5-cyclohexyl indan-1-carboxylic acid (Clidanac) are well known anti-inflammatory agents, whilst indan-1,3-dione is an anticoagulant. Over the years, several indan derivatives, particularly indan acid derivatives, have been synthesized and their potential analgesic and anti-inflammatory properties have been studied. This review critically appraises various synthetic protocols and structure-activity-relationships of indan acids as analgesic and anti-inflammatory agents with low ulcerogenicity.