Occurrences, mechanism of action, structural activity relationship and various pharmacological activities of thiadiazole and their derivatives

Abstract

In the recent times, many people around the world are suffering drug resistant in most of the antibiotics used in different circumferences. In order to overcome the antibiotic resistance problem, there is need to use of existing antibiotics consciously and prepare novel compounds which exhibit high therapeutic profile against different pathogens with least resistance. In this review we discussed the thiadiazole derivatives and their different biological activities such as anti-inflammatory, anti-helicobacter pylori, anti-microbial, anti-cancer, antiviral, anti-depressant, analgesic, herbicidal and adenosine A3 receptor inhibitor, besides that this review also provides a detailed information about structural activity relationship (SAR) of such a compounds prepared by different medicinal chemist to date. In general, SAR is the smartest tool among the medicinal chemist to create a better therapeutic efficacy and high safety bioactive molecule in a short span of time. Besides that, we pointed out here different challenges of thiadiazole derivatives and its feature perspectives.