Vol 9, No 2 (2019)

The phenothiazine nucleus is one of the most important and trusted heterocyclic ring, which is commonly found in natural products and medicinal agents. It was discovered during the 1940s, since many scientists were found various newer derivatives and established their biological activities. The recently developed phenothiazine derivatives were exhibiting significant activities such as tranquillizer, antibacterial, antiparkinsonian, antifungal, anticancer, antiviral, anti-inflammatory, antihistaminic, anti-malarial, anti-filarial, trypanocidal, anticonvulsant, analgesic, immunosuppressive and multidrug resistance reversal properties. In the presented study, an attempt had been made to systematize the recent research finding of many newer phenothiazine derivatives including method of synthesis, structure and evaluated in vitro and in vivo promising biological activities and pharmacological properties. This review emphasises the two decades of research work on newer synthesis, structure and biological activities of different phenothiazine derivatives.