Hybrid Systems of Delivery of Long-Acting Drugs Based on Gentamicin Sulfate, Silver, and Copper Nanoparticles, and Gelatin Biopolymer Matrices

Abstract

Using the method of cryochemical synthesis, systems of prolonged release of gentamicin sulfate modified with silver (2–30 nm) and copper (1–9 nm) nanoparticles from cryostructured biopolymer matrices based on gelatin with a pore size of 10‒50 μm are obtained. The composition and structure of the systems are confirmed by the data of IR, UV, and NMR spectroscopy; TEM; SEM; and thermoanalytical methods of analysis, and the rate of release of the drug is determined by conductometry. Hybrid composites based on metals and gentamicin sulfate showed greater activity in suppressing the growth of E. coli 52 and S. aureus 144 than their components separately.