PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES OF ASSOCIATES OF COPPER NANOPARTICLES

Abstract

Abstract—The physicochemical parameters of associates of unstabilized copper nanoparticles (NPs) obtained by the plasma-chemical method were studied. Optical methods were used to determine the size of NP associates, including atomic force microscopy, spectrophotometry, and fluorometry. The sizes of copper NPs varied from 30 to 75 nm, and the sizes of NP associates, from 481.1 to 1037 nm. The phase composition of copper NPs was analyzed by X-ray diffractometry using a Rigaku Ultima IV multifunctional X-ray diffractometer. An oxide film without an admixture of organic molecules was found on the surface of NP associates. The effect of copper NPs on an A549 cell culture was studied. A change was observed in the biochemical parameters of blood serum of outbred mice under the influence of copper NPs. The antitumor effect of copper NPs was revealed, and its intensity was compared to different methods of administering NP to animals with fibrosarcoma (S-45) and Pliss lymphosarcoma.