The effect of biologically active feed additives in the diet on the hematological parameters of fish

封面

如何引用文章

全文:

详细

Hematological analysis is one of the main tools for assessing the effect of various feed additives on the animal body. The article presents the results of the effect of biologically active feed additives on the growth and morpho-biochemical parameters of the blood of carp (Cyprinus carpio). For 42 days, in addition to the basic diet, vanillin (I experimental), probiotic (II experimental), vanillin + probiotic complex (III experimental), vanillin + ultrafine particles of silicon dioxide + probiotic (IV experimental) or vanillin + ultrafine particles of silicon dioxide + Zn + I + Cr + Co complex (V experimental), were included in the yearlings' diet. It was found that feed additives had a different effect on the body of fish. If in the I, II and V experimental groups an increase in live weight was recorded to 10.2% (P≤0.01), then in the III and IV experimental groups the growth of fish decreased relative to the control to 19.6% (P≤0.001). Morphological blood analysis showed that biologically active feed additives contributed to an increase (P≤0.05) in hemoglobin in all experimental groups, with the exception of groups III and V, where a decrease (P≤0.05) was recorded. In the study of biochemical parameters, a general trend of changes in a number of indicators was recorded in groups whose diet included probiotics. There were significant differences in the concentration of ALT, total protein, triglycerides and cholesterol. Thus, the effect of biologically active feed additives contributed to obtaining distinctive results. Positive results on hematological parameters were established in the I and V experimental groups, while ambiguous results were found in the II, III and IV groups.

作者简介

Marina Mingazova

Orenburg State University

编辑信件的主要联系方式.
Email: ms.mingazova@gmail.com
ORCID iD: 0000-0002-2818-1312

Assistant of the Department of Biotechnology of Animal Raw Materials and Aquaculture

俄罗斯联邦, Orenburg

Elena Miroshnikova

Orenburg State University

Email: elenaakva@rambler.ru
ORCID iD: 0000-0003-3804-5151

Dr. Sci. (Biology), Professor, Head of the Department of Biotechnology of Animal Raw Materials and Aquaculture

俄罗斯联邦, Orenburg

Yulia Kilyakova

Orenburg State University

Email: fish-ka06@mail.ru
ORCID iD: 0000-0002-2385-264X

Cand. Sci. (Biology), Associate Professor, Department of Biotechnology of Animal Raw Materials and Aquaculture

俄罗斯联邦, Orenburg

Azamat Arinzhanov

Orenburg State University

Email: arin.azamat@mail.ru
ORCID iD: 0000-0001-6534-7118

Cand. Sci. (Agriculture), Associate Professor, Department of Biotechnology of Animal Raw Materials and Aquaculture

俄罗斯联邦, Orenburg

参考

  1. Akhmetova VV, Vasina SB. Assessment of morphological and biochemical blood picture of carps grown in LLC «Fish Farm» in Ulyanovsk district of Ulyanovsk region. Vestnik of Ulyanovsk State Agricultural Academy. 2015;3(31):53-58. doi: 10.18286/1816-4501-2015-3-53-58
  2. Mingazova MS, Miroshnikova EP, Kilyakova YuV, Arinzhanov AЕ. Biological effect of feed additives on carp. Animal Husbandry and Fodder Production. 2023a;106(3):121-137. doi: 10.33284/2658-3135-106-3-121
  3. Arinzhanova MS, Miroshnikova EP, Arinzhanov AЕ, Kilyakova JV. Biological effect of ultrafine particles of SiO2, probiotic preparation Bifidobiom and a complex of microelements on the body of carp. Animal Husbandry and Fodder Production. 2023b;106(1):48-66. doi: 10.33284/2658-3135-106-1-48
  4. Karpenko LYu, Polistovskaya PA, Enukashvili AI, Balykina AB. Influence of cadmium on hematological indicators of carp. International Bulletin of Veterinary Medicine. 2020;1:92-96. doi: 10.17238/issn2072-2419.2020.1.92
  5. Zueva MS, Miroshnikova EP, Arinzhanov AE, Kilyakova YuV. The effect of probiotics on the elemental composition of muscle tissue in carp. Animal Husbandry and Fodder Production. 2023;106(2):8-20. doi: 10.33284/2658-3135-106-2-8
  6. Arinzhanova MS, Miroshnikova EP, Arinzhanov AЕ, Kilyakova YuV. Influence of ultrafine particles of silicon dioxide on the growth and amino acid composition of fish liver. Animal Husbandry and Fodder Production. 2022;105(2):8-16. doi: 10.33284/2658-3135-105-2-8
  7. Kilyakova YuV, Miroshnikova EP, Arinzhanov AE, Arinzhanova MS. Influence of phytobiotic feed additives on growth and morphobiochemical parameters of fish blood. Animal Husbandry and Fodder Production. 2022;105(3):115-125. doi: 10.33284/2658-3135-105-3-115
  8. Golovina NA, Poddubnaya AP, Mankirova VB. Effect of some carp diseases on haematological parameters. Bulletin of Zoology. 1977;5:29-33.
  9. Zhandalgarova AD, Bakhareva AA, Grozesku YuN. Probiotic drug effect evaluation on the enterosorbent “Florin forte” on the physiological and immunological state of bester. Vestnik of Astrakhan State Technical University. Series: Fishing Industry. 2023;4:42-47. doi: 10.24143/2073-5529-2023-4-42-47
  10. Zueva MS. Modern experience of including biologically active feed additives in the diet of fish (review). Animal Husbandry and Fodder Production. 2022;105(4):146-164. doi: 10.33284/2658-3135-105-4-146
  11. Stepantsova GE, Nizhnikova EV, Nefedova NP, Vorobjov VI, Lemper OT. Effect study of microelements on fiziologo-biochemical indicators of the rainbow trout. Journal of Science and Education of North-West Russia. 2018;4(2):128-135.
  12. Ilyashenko AN. Bacillus probiotics in the feeding and maintenance of hydrobionts (review). Animal Husbandry and Fodder Production. 2022;105(4):165-180. doi: 10.33284/2658-3135-105-4-165
  13. Duskaev GK, Sheida EV, Kvan OV, Kurilkina MYa, Rakhmatullin ShG. On the use of vanillin in diets for broilers. Poultry farming. 2023;3:14-19. doi: 10.33845/0033-3239-2023-72-3-14-19
  14. Mingazova MS, Miroshnikova EP, Arinzhanov AЕ, Kilyakova YuV. Concentration of chemical elements in carp muscle tissue when biologically active substances are included in the diet. Animal Husbandry and Fodder Production. 2023b;106(4):18-29. doi: 10.33284/2658-3135-106-4-18
  15. Mingazova MS, Miroshnikova EP, Arinzhanov AE, Kilyakova YuV. General understanding of bacterial quorum sensing and use of quorum inhibitors in aquaculture (review). Animal Husbandry and Fodder Production. 2024;107(1):128-146. doi: 10.33284/2658-3135-107-1-128
  16. Omelchenko SO, Сhesnokova II, Zalevskaya IN. Peculiarities of nitrogen metabolism and nitrosamines content in tissues of black sea fish species belonging to different ecological groups. Scientific Notes of V.I. Vernadsky Crimean Federal University. Biology. Chemistry. 2016;2-68(2):47-57.
  17. Abdel-Rahman AN, Amer SA, Behairy A, Younis EM, Abdelwarith AA, Osman A, Moustafa AA, Davies SJ, Ibrahim RE. Using Azadirachta indica protein hydrolysate as a plant protein in Nile tilapia (Oreochromis niloticus) diet: Effects on the growth, economic efficiency, antioxidant-immune response and resistance to Streptococcus agalactiae. Journal of Animal Physiology and Animal Nutrition.2023;107(6):1502-1516. doi: 10.1111/jpn.13857
  18. Abdel-Razek N, El-Sabbagh N, Khalil RH, Abdel-Tawwab M. Prophylactic effects of dietary caper (Capparis spinosa) extracts on the control of Streptococcus agalactiae infection, growth, immune-antioxidant, and inflammation cytokine responses of Nile tilapia fingerlings. Fish & Shellfish Immunology. 2023;142:109126. doi: 10.1016/j.fsi.2023.109126
  19. Akter S, Jahan N, Rohani F, Akter Y, Shahjahan M. Chromium supplementation in diet enhances growth and feed utilization of striped catfish (Pangasianodon hypophthalmus). Biological Trace Element Research. 2021;199:4811-4819. doi: 10.1007/s12011-021-02608-2
  20. Chiu S-T, Chu T-W, Simangunsong T, Ballantyne R, Chiu C-S, Liu C-H. Probiotic, Lactobacillus pentosus BD6 boost the growth and health status of white shrimp, Litopenaeus vannamei via oral administration. Fish & Shellfish Immunology. 2021;117:124-135. doi: 10.1016/j.fsi.2021.07.024
  21. Dawood MAO, Abdo SE, Gewaily MS, Moustafa EM, SaadAllah MS, AbdEl-kader MF, Hamouda AH, Omar AA, Alwakeel RA. The influence of dietary β-glucan on immune, transcriptomic, inflammatory and histopathology disorders caused by deltamethrin toxicity in Nile tilapia (Oreochromi sniloticus). Fish & Shellfish Immunology. 2020;98:301-311. doi: 10.1016/j.fsi.2020.01.035
  22. Diab AM, Salem RM, Abeer E-KMS, Ali GIE, El-Habashi N. Experimental ochratoxicosis A in Nile tilapia and its amelioration by some feed additives. International Journal of Veterinary Science and Medicine. 2018;6(2):149-158. doi: 10.1016/j.ijvsm.2018.09.004
  23. Ding Q, Lu C, Hao Q, Zhang Q, Yang Y, Olsen RE, Ringo E, Ran C, zhang Z, Zhou Z. Dietary succinate impacts the nutritional metabolism, protein succinylation and gut microbiota of zebrafish. Frontiers in Nutrition. 2022;9:894278. doi: 10.3389/fnut.2022.894278
  24. Fiorella KJ, Okronipa H, Baker K, Heilpern S. Contemporary aquaculture: implications for human nutrition. Current Opinion in Biotechnology. 2021;70:83-90. doi: 10.1016/j.copbio.2020.11.014
  25. Fuentes C, Fuentes A, Barat JM, Ruiz MJ. Relevant essential oil components: a minireview on increasing applications and potential toxicity. Toxicology Mechanisms and Methods. 2021;31(8):559-565. doi: 10.1080/15376516.2021.1940408
  26. Ghirmai S, Wu H, Axelsson M, Matsuhira T, Sakai H, Undeland I. Exploring how plasma- and muscle-related parameters affect trout hemolysis as a route to prevent hemoglobin-mediated lipid oxidation of fish muscle. Scientific Reports. 2022;12(1):13446. doi: 10.1038/s41598-022-16363-4
  27. Gupta DS, Kumar MS. The implications of quorum sensing inhibition in bacterial antibiotic resistance- with a special focus on aquaculture. Journal of Microbiological Methods. 2022;203:106602. doi: 10.1016/j.mimet.2022.106602
  28. Hassaan MS, Soltan MA, Mohammady EY, Elashry MA, El-Haroun ER, Davies SJ. Growth and physiological responses of Nile tilapia, Oreochromis niloticus fed dietary fermented sunflower meal inoculated with Saccharomyces cerevisiae and Bacillus subtilis. Aquaculture. 2018;495:592-601. doi: 10.1016/j.aquaculture.2018.06.018
  29. Isla A, Sánchez P, Ruiz P, Albornoz R, Pontigo JP, Rauch MC, Hawes C, Vargas-Chacoff L, Yáñez AJ. Effect of low-dose Piscirickettsia salmonis infection on haematological-biochemical blood parameters in Atlantic salmon (Salmo salar). Journal of Fish Biology. 2022;101(4):1021-1032. doi: 10.1111/jfb.15167
  30. Kanu KC, Okoboshi AC, Otitoloju AA. Haematological and biochemical toxicity in freshwater fish Clarias gariepinus and Oreochromis niloticus following pulse exposure to atrazine, mancozeb, chlorpyrifos, lambda-cyhalothrin, and their combination. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2023;270:109643. doi: 10.1016/j.cbpc.2023.109643
  31. Kesbic OS, Acar U, Hassaan MS, Yilmaz S, Guerrera MC, Fazio F. Effects of tomato paste by-product extract on growth performance and blood parameters in common carp (Cyprinus carpio). Animals (Basel). 2022;12(23):3387. doi: 10.3390/ani12233387
  32. Khan S, Moore RJ, Stanley D, Chousalkar KK. The gut microbiota of laying hens and its manipulation with prebiotics and probiotics to enhance gut health and food safety. Applied and Environmental Microbiology. 2020;86(13):e00600-20. doi: 10.1128/AEM.00600-20
  33. Klykken C, Khan E, Karlsen C, Reed AK, Attramadal KJK, Olsen RE, Boissonnot L. Nephrocalcinosis in juvenile farmed Atlantic Salmon (Salmo salar) may be linked to osmoregulatory stress. Journal of Fish Diseases. 2023;46(9):13815. doi: 10.1111/jfd.13815
  34. Liang Q, Yuan M, Xu L, Lio E, Zhang F, Mou H, Secundo F. Application of enzymes as a feed additive in aquaculture. Marine Life Science & Technology. 2022;4(2):208-221. doi: 10.1007/s42995-022-00128-z
  35. Liu WB, Wang MM, Dai LY, Dong AH, Yuan XD, Yuan XD, Yuan SL, Tang Y, Liu JH, Peng LY, Xiao YM. Enhanced immune response improves resistance to cadmium stress in triploid crucian carp. Frontiers in Physiology. 2021;12:666363. doi: 10.3389/fphys.2021.666363
  36. Liu Y, Liu S, Huang J, Liu Y, Wang Q, Chen J, Sun L, Tu W. Mitochondrial dysfunction in metabolic disorders induced by per- and polyfluoroalkyl substance mixtures in zebrafish larvae. Environment International. 2023a;176:107977. doi: 10.1016/j.envint.2023.107977
  37. Liu Y, Sun L, Huo Y-X, Guo S. Strategies for improving the production of bio-based vanillin. Microbial Cell Factories. 2023b;22(1):147. doi: 10.1186/s12934-023-02144-9
  38. Nabi N, Ahmed I, Wani GB. Hematological and serum biochemical reference intervals of rainbow trout, Oncorhynchus mykiss cultured in Himalayan aquaculture: Morphology, morphometrics and quantification of peripheral blood cells. Saudi Journal of Biological Sciences. 2022;29(4):2942-2957. doi: 10.1016/j.sjbs.2022.01.019
  39. Naguib M, Mahmoud UM, Mekkawy IA, Sayed AEH. Hepatotoxic effects of silver nanoparticles on Clarias gariepinus; Biochemical, histopathological, and histochemical studies. Toxicology Reports. 2020;7:133-141. doi: 10.1016/j.toxrep.2020.01.002
  40. Nami Y, Kahieshesfandiari M, Lornezhad G, Kiani A, Elieh-Ali-Komi D, Jafari M, Jaymand M, Haghshenas B. Administration of microencapsulated Enterococcus faecium ABRIINW.N7 with fructo-oligosaccharides and fenugreek on the mortality of tilapia challenged with Streptococcus agalactiae. Frontiers in Veterinary Sciences. 2022;9:938380. doi: 10.3389/fvets.2022.938380
  41. Naylor RL, Hardy RW, Buschmann AH, Bush SR, Cao L, Klinger DH, Little DC, Lubchenco J, Shumway SE, Troell M. A 20-year retrospective review of global aquaculture. Nature. 2021;591:551-563. doi: 10.1038/s41586-021-03308-6
  42. Ni M, Liu M, Lou J, Mi G, Yuan J, Gu Z. Stocking density alters growth performance, se- rum biochemistry, digestive enzymes, immune response, and muscle quality of largemouth bass (Microp- terus salmoides) in in-pond raceway system. Fish Physiology and Biochemistry. 2021;47(4):1243-1255. doi: 10.1007/s10695-021-00948-3
  43. Puri P, Sharma JG, Singh R. Biotherapeutic microbial supplementation for ameliorating fish health: developing trends in probiotics, prebiotics, and synbiotics use in finfish aquaculture. Animal Health Research Reviews. 2022;23(2):113-115. doi: 10.1017/S1466252321000165
  44. Rahman M, Paul SI, Rahman A, Haque S, Ador AA, Foysal J, Islam T, Rahman M. Suppression of streptococcosis and modulation of the gut bacteriome in nile tilapia (Oreochromis niloticus) by the marine sediment bacteria Bacillus haynesii and Advenella mimigardefordensis. Microbiology Spectrum. 2022;10(6):e0254222. doi: 10.1128/spectrum.02542-22
  45. Siebel H, Baßmann B, Rebl A. Blood will tell: what hematological analyses can reveal about fish welfare. Frontiers in Veterinary Science. 2021;8:616955. doi: 10.3389/fvets.2021.616955
  46. Singh M, Barman AS, Devi AL, Devi AG, Pandey PK. Iron mediated hematological, oxidative and histological alterations in freshwater fish Labeo rohita. Ecotoxicology and Environmental Safety. 2019;170:87-97. doi: 10.1016/j.ecoenv.2018.11.129
  47. Song X, Liu H, Jin J, Han D, Zhu X, Yang Y, Xie S. Data mining evidences variabilities in glucose and lipid metabolism among fish strains: a case study on three genotypes of gibel carp fed by different carbohydrate sources. Aquaculture Nutrition. 2023;2023:7589827. doi: 10.1155/2023/7589827
  48. Syed R, Masood Z, Hassan HUI, Khan W, Mushtaq S, Ali A, Gui Y, Jafari H, Habib A, Ali Shah MI, Gabol K, Gul H, Ullah A. Growth performance, haematological assessment and chemical composition of Nile tilapia, Oreochromis niloticus (Linnaeus, 1758) fed different levels of Aloe vera extract as feed additives in a closed aquaculture system. Saudi Journal of Biological Sciences. 2022;29(1):296-303. doi: 10.1016/j.sjbs.2021.08.098
  49. Torres M, Dessaux Y, Llamas I. Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review. Marine drugs. 2019;17(3):191. doi: 10.3390/md17030191
  50. Ullah M, Yousafzai AM, Muhammad I, Ullah SA, Zahid M, Khan MI, Khan K, Khayyam, Nayab GE, Aschner M, Alsharif KF, Alzahrani KJ, Khan H. Effect of cypermethrin on blood hematology and biochemical parameters in fresh water fish Ctenopharyngodon idella (Grass Carp). Cell and Molecular Biology. 2022;68(10-10):15-20. doi: 10.14715/cmb/2022.68.10.3
  51. Wang H, Feng Y, Ming M, Song J, Chen Z, Xiao Z. Amelioration of Cd-induced bioaccumulation, hematological parameters, and heat shock protein-related genes by Vitamin C on common carp. Comparative biochemistry and physiology. Toxicology & Pharmacology. 2022;258:109362. doi: 10.1016/j.cbpc.2022.109362
  52. Witeska M, Kondera E, Bojarski B. Hematological and hematopoietic analysis in fish toxicology-a review. Animals (Basel). 2023;13(16):2625. doi: 10.3390/ani13162625
  53. Xu M, Wang T, Wang J, Wan W, Wang Z, Guan D, Sun H. An evaluation of mixed plant protein in the diet of Yellow River carp (Cyprinus carpio): growth, body composition, biochemical parameters, and growth hormone/insulin-like growth factor 1. Fish Physiol Biochem. 2019;45(4):1331-1342. doi: 10.1007/s10695-019-00641-6
  54. Zhang L, Liu Z, Deng Y, He C, Liu W, Li X. The benefits of nanosized magnesium oxide in fish Megalobrama amblycephala: evidence in growth performance, redox defense, glucose metabolism, and magnesium homeostasis. Antioxidants (Basel). 2023;12(7):1350. doi: 10.3390/antiox12071350

补充文件

附件文件
动作
1. JATS XML

版权所有 © Мингазова М.S., Мирошникова Е.P., Килякова Ю.V., Аринжанов А.E., 2025

Creative Commons License
此作品已接受知识共享署名 4.0国际许可协议的许可

Согласие на обработку персональных данных с помощью сервиса «Яндекс.Метрика»

1. Я (далее – «Пользователь» или «Субъект персональных данных»), осуществляя использование сайта https://journals.rcsi.science/ (далее – «Сайт»), подтверждая свою полную дееспособность даю согласие на обработку персональных данных с использованием средств автоматизации Оператору - федеральному государственному бюджетному учреждению «Российский центр научной информации» (РЦНИ), далее – «Оператор», расположенному по адресу: 119991, г. Москва, Ленинский просп., д.32А, со следующими условиями.

2. Категории обрабатываемых данных: файлы «cookies» (куки-файлы). Файлы «cookie» – это небольшой текстовый файл, который веб-сервер может хранить в браузере Пользователя. Данные файлы веб-сервер загружает на устройство Пользователя при посещении им Сайта. При каждом следующем посещении Пользователем Сайта «cookie» файлы отправляются на Сайт Оператора. Данные файлы позволяют Сайту распознавать устройство Пользователя. Содержимое такого файла может как относиться, так и не относиться к персональным данным, в зависимости от того, содержит ли такой файл персональные данные или содержит обезличенные технические данные.

3. Цель обработки персональных данных: анализ пользовательской активности с помощью сервиса «Яндекс.Метрика».

4. Категории субъектов персональных данных: все Пользователи Сайта, которые дали согласие на обработку файлов «cookie».

5. Способы обработки: сбор, запись, систематизация, накопление, хранение, уточнение (обновление, изменение), извлечение, использование, передача (доступ, предоставление), блокирование, удаление, уничтожение персональных данных.

6. Срок обработки и хранения: до получения от Субъекта персональных данных требования о прекращении обработки/отзыва согласия.

7. Способ отзыва: заявление об отзыве в письменном виде путём его направления на адрес электронной почты Оператора: info@rcsi.science или путем письменного обращения по юридическому адресу: 119991, г. Москва, Ленинский просп., д.32А

8. Субъект персональных данных вправе запретить своему оборудованию прием этих данных или ограничить прием этих данных. При отказе от получения таких данных или при ограничении приема данных некоторые функции Сайта могут работать некорректно. Субъект персональных данных обязуется сам настроить свое оборудование таким способом, чтобы оно обеспечивало адекватный его желаниям режим работы и уровень защиты данных файлов «cookie», Оператор не предоставляет технологических и правовых консультаций на темы подобного характера.

9. Порядок уничтожения персональных данных при достижении цели их обработки или при наступлении иных законных оснований определяется Оператором в соответствии с законодательством Российской Федерации.

10. Я согласен/согласна квалифицировать в качестве своей простой электронной подписи под настоящим Согласием и под Политикой обработки персональных данных выполнение мною следующего действия на сайте: https://journals.rcsi.science/ нажатие мною на интерфейсе с текстом: «Сайт использует сервис «Яндекс.Метрика» (который использует файлы «cookie») на элемент с текстом «Принять и продолжить».