Ministry of Health of the Russian Federation The role of the systemic inflammatory response in the pathogenesis of covid syndrome: molecular mechanisms and clinical manifestations

postcovoid syndrome (ASCS) is one of the most complex clinical and pathogenetic consequences of SARS-CoV-2 infection, characterized by persistent symptoms and disorders that persist weeks and months after the acute period of the disease. The most significant pathogenetic link, according to recent studies, is a systemic inflammatory response mediated by the activation of pro-inflammatory cytokines, disorders in the immune system and endothelial dysfunction. The purpose of this work is to analyze the molecular mechanisms of systemic inflammation in ASD and their clinical manifestations based on empirical data. Methods of biochemical blood analysis, clinical and laboratory examinations, as well as a retrospective analysis of patients' medical histories were used. The results obtained suggest that the persistence of pro-inflammatory mediators is closely related to the clinical picture of ASD, which opens up opportunities for targeted therapy.

kidney syndrome, systemic inflammatory response, cytokines, IL-6, TNF-?, molecular mechanisms, clinical manifestations