Comparative multicriteria evaluation of ready-to-use oral nutritional supplements for patients with cancer

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Abstract

BACKGROUND: More than half of patients with cancer have nutritional deficiency. Nutritional support positively affects the outcomes of antitumor treatment. However, no comparative assessment of ready-to-use oral nutritional supplements for patients with cancer has been conducted in Russia.

AIM: The work aimed to perform a comparative evaluation of ready-to-use oral nutritional supplements for patients with cancer using multicriteria analysis.

METHODS: We evaluated 18 ready-to-use sip feeds (oral nutritional formulas) available in Russia by the start of 2025 based on 17 criteria. A scenario approximating real-world clinical practice was used for comparative analysis of the nutritional value of the formulas. We modeled nutritional support for a patient with a body weight of 77 kg, with a daily protein intake of 1.5 g per kilogram of body weight and with 50% of this amount provided by the formula. Based on this scenario, the volume of each formula was calculated to contain 57.75 g of protein. Each criterion was assigned values obtained from primary information sources. For aggregation (deriving the weighted total score), criterion values were multiplied by their respective weights and summed for each formula.

RESULTS: The highest aggregated scores were obtained for Nutridrink Compact Protein, Nutridrink Compact with Fiber, and Supportan Drink. The smallest volume required to meet the daily protein target intake was observed for Supportan Drink and Nutridrink Compact Protein (361 and 396 mL, respectively). Vitamin content exceeded the recommended intake levels in all analyzed formulas. The smallest excess (≤ 200%) was noted in Nutricomp Drink Plus, Nutricomp Drink Plus Fiber, Nutridrink Compact, and Nutrien. Mineral concentrations exceeded the recommended intake levels by the smallest margin (≤ 200%) in Leovit Onco Protein Detox Cocktail, Nutricomp Drink Plus, and Nutrien Standard. The caloric value ranged from 1200 to 2000 kcal/day and was lowest in Nutridrink Compact with Fiber and Fresubin Drink 3.2 kcal, and highest in Resource 2.0 + Fiber and Fresubin Drink 2 kcal with Fiber. The greatest variety of flavor options was observed for Nutridrink Compact Protein (8 options). The most extensively studied product was Nutridrink Compact Protein (11 publications).

CONCLUSION: The multicriteria analysis suggested that Nutridrink Compact Protein appears to be the optimal formula for patients with cancer. A promising direction for future research is to compare these findings with the cost of the evaluated products as part of a separate nutrition–economic study.

About the authors

Alexander G. Tolkushin

Independent Research Company “Smart Choice”

Author for correspondence.
Email: tolkushin@inbox.ru
ORCID iD: 0000-0002-6803-4763
SPIN-code: 7706-3809

Cand. Sci. (Pharmacy)

Russian Federation, Moscow

Ekaterina A. Pyrieva

Federal Research Center of Nutrition, Biotechnology and Food Safety

Email: pyrieva@ion.ru
ORCID iD: 0000-0002-9110-6753
SPIN-code: 3323-3049

MD, Cand. Sci. (Medicine), Assistant Professor

Russian Federation, Moscow

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Supplementary files

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2. Fig. 1. Flowchart of study sample formation (according to STROBE criteria). STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) is an international standard aimed at improving the quality of reporting in observational epidemiologic studies.

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3. Fig. 2. Ranking of analyzed ready-to-use sip-feeds according to the multicriteria analysis method by score.

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4. Fig. 3. Weight of criteria for evaluating ready-to-use sip-feeds. Data are presented as mean ± standard deviation (M ± SD); 95% CIs are shown as error bars.

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