The problem of factors of mental development and health of children born with the use of assisted reproductive technologies
- Authors: Bokhan T.G.1, Silaeva A.V.1, Terekhina O.V.1, Leshchinskai S.B.1, Shabalovskaya M.V.1
-
Affiliations:
- Tomsk State University
- Issue: Vol 17, No 1 (2025)
- Pages: 389-414
- Section: Public Health and Preventive Medicine
- Published: 28.02.2025
- URL: https://journal-vniispk.ru/2658-6649/article/view/309217
- DOI: https://doi.org/10.12731/10.12731/2658-6649-2025-17-1-1045
- EDN: https://elibrary.ru/MMLOBP
- ID: 309217
Cite item
Full Text
Abstract
Background. The lack of data on long-term prognosis of the development of children born after IVF and isolated examples of interdisciplinary research indicate the need to systematize data on the factors that determine the characteristics of their development and health.
Purpose. The literature review is aimed at identifying the factors and features of their systemic interaction that determine the development of children born using IVF.
Materials and methods. Using keywords, an analysis of foreign and domestic studies included in databases of scientific publications which presented the results of the influence of factors on the health status and development indicators of children born after IVF was carried out. The studies are included in the scientific citation databases of the library of the Russian Foundation for Basic Research, Russian Science Citation Index, CyberLeninka, Scopus, Web of Science, and others (publication years 2010–2024).
Results. The list of factors proves that children born after IVF are influenced by special conditions, not all of them can be controlled and influenced by doctors and medical technologies. The health potential of a child in the early stages of ontogenesis is determined primarily by biological factors, but the success of development at further age stages is determined by the quality of the social development situation that the child’s parents create through their interaction with him, reliable and friendly marital relationships, stability of psychological and mental health, economic resources, etc.
Conclusion. The results of the systemic interaction of factors that have a direct and indirect impact on the health and mental development of the children indicate the feasibility of introducing medical, psychological and pedagogical preventive programs to support families with children born after IVF.
About the authors
Tatiana G. Bokhan
Tomsk State University
Author for correspondence.
Email: btg960@mail.ru
ORCID iD: 0000-0003-1454-3869
SPIN-code: 2891-7745
Scopus Author ID: 5682013300
ResearcherId: O-1353-2014
Dr. Sc. (Psychology), Professor, Head of the Department of Psychotherapy and Psychological Counseling
Russian Federation, 36, Lenin Ave., Tomsk, 634050, Russian Federation
Anna V. Silaeva
Tomsk State University
Email: silaevaav@yandex.ru
ORCID iD: 0000-0003-2251-5200
SPIN-code: 7582-7990
Scopus Author ID: 57207571308
ResearcherId: P-5732-2016
PhD in Psychology, Associate Professor, Department of Psychotherapy and Psychological Counseling
Russian Federation, 36, Lenin Ave., Tomsk, 634050, Russian Federation
Olga V. Terekhina
Tomsk State University
Email: doterekhina@mail.ru
ORCID iD: 0000-0003-0964-9175
SPIN-code: 2726-3340
Scopus Author ID: 571940902
ResearcherId: F-1362-2019
PhD in Psychology, Associate Professor, Department of Psychotherapy and Psychological Counseling
Russian Federation, 36, Lenin Ave., Tomsk, 634050, Russian Federation
Svetlana B. Leshchinskai
Tomsk State University
Email: s_leschins94@mail.ru
ORCID iD: 0000-0001-9564-085X
SPIN-code: 8965-4260
Scopus Author ID: 57204199403
ResearcherId: N-3029-2014
PhD in Psychology, Associate Professor, Department of Psychotherapy and Psychological Counseling
Russian Federation, 36, Lenin Ave., Tomsk, 634050, Russian Federation
Marina V. Shabalovskaya
Tomsk State University
Email: m_sha79@mail.ru
ORCID iD: 0000-0003-2622-3491
SPIN-code: 5949-5444
Scopus Author ID: 57193768514
ResearcherId: S-3794-2016
PhD in Psychology, Associate Professor, Department of Psychotherapy and Psychological Counseling
Russian Federation, 36, Lenin Ave., Tomsk, 634050, Russian Federation
References
- Belyayeva, I. A., Namazova-Baranova, L. S., Baranov, A. A., Efendieyva, K. E., Karkashadze, G. A., Dedyukhina, E. S., Serebryakova, E. N., Konstantinidi, T. A., Gogoberashvili, T. Yu., & Molodchenkov, A. I. (2022). Long-term development and health of children conceived using assisted reproductive technologies. Questions of Modern Pediatrics, 21(2), 72–82. https://doi.org/10.15690/pf.v19i2.2404
- Bokhan, T. G. (2023). Individual differences in cognitive, motivational, and psycho-emotional processes in learning and development in preschool and school-age children (Stage 1). Research report. Tomsk: National Research Tomsk State University. № GR 223030200070-5.
- Bokhan, T. G., Silaeva, A. V., Shabalovskaia, M. V., Leschinskaia, S. B., & Terekhina, O. V. (2023). Parents' psychological states and subjective evaluations of family relationships as predictors of mental development and health in four-year-old children born via IVF. Psychotherapy, Psychiatry and Clinical Psychology, 14(3), 215–227. https://doi.org/10.34883/PI.2023.14.3.002
- Bokhan, T. G., Silaeva, A. V., Terekhina, O. V., Shabalovskaia, M. V., Leschinskaia, S. B., & Gaifulina, Zh. F. (2022). Mother's health as a factor influencing mental development and health of children born via in vitro fertilization: Longitudinal study. Psychotherapy, Psychiatry and Clinical Psychology, 13(4), 407–420. https://doi.org/10.34883/PI.2022.13.4.010
- Leschinskaia, S. B. (2022). Marriage and parenting relations in families conceiving a child through IVF and their contribution to child’s mental development. Candidate of Psychological Sciences thesis. Tomsk. 194 p.
- Malyskina, A. I., Matveyeva, E. A., Filkina, O. M., & Ermakova, I. S. (2019). Health status of infants in the first year of life born after in vitro fertilization. Russian Bulletin of Perinatology and Pediatrics, 64(1), 39–45. https://doi.org/10.21508/1027-4065-2019-64-1-39-45
- Mikheyeva, E. M., Penkina, N. I., & Yuditsky, A. D. (2023). Risk factors for high viral infection rates in children born using assisted reproductive technologies. Russian Bulletin of Perinatology and Pediatrics, 68(6), 31–35. https://doi.org/10.21508/1027-4065-2023-68-6-31-35
- Murzakhanova, A. F., Oslopov, V. N., & Khazova, E. V. (2020). Health status of children born after in vitro fertilization: Probable risks and complications. Practical Medicine, 18(3), 43–50. https://doi.org/10.32000/2072-1757-2020-3-43-50
- Pitsekhelava, E. G., Strizhakov, A. N., Timokhina, E. V., Belousova, V. S., Bogomasova, I. M., & Garina, A. O. (2018). Health of children after assisted reproductive technologies: probable risks and possible complications. Obstetrics, Gynecology and Reproduction, 12(3), 56–63. https://doi.org/10.17749/2313-7347.2018.12.3.056-063
- Saveleva, G. M., Kurcer, M. A., & Karachunskaia, E. M. (2010). Health of children born after IVF. Obstetrics and Gynecology, (5), 49–54.
- Savevshcheva, S. S. (2017). Prenatal attachment: Concept, structure, determinants. World of Science, Culture and Education, (62), 243–248.
- Silaeva, A. V. (2021). Mother's health as a factor in mental development and health of children born via in vitro fertilization. Candidate of Psychological Sciences thesis. Tomsk. 205 p.
- Solovyeva, E. V. (2015). Mental development of early childhood conceived via IVF and their interaction with mothers. Candidate of Psychological Sciences thesis. Moscow. 217 p.
- Stepanova, E. M. (2023). Thyroid status of reproductive-age women living in endemic goiter areas. Siberian Journal of Life Sciences and Agriculture, 15(5), 97–116. https://doi.org/10.12731/2658-6649-2023-15-5-928
- Temirkhanova, K. T., Deriagina, L. E., Pyatibratskaya, E. D., & Pyatibratsky, A. O. (2022). Psychophysiological profile of adolescents whose mothers lived in military conflict zones before pregnancy. Siberian Journal of Life Sciences and Agriculture, 14(5), 208–225. https://doi.org/10.12731/2658-6649-2022-14-5-208-225
- Terekhina, O. V., Shabalovskaia, M. V., Markov, A. D., & Yarigina, A. M. (2023). Relationship between trace element balance and mental development in children born via IVF. In Scientific Research in the Modern World: Experiences, Problems, and Development Perspectives (pp. 197–202). Ufa: Bulletin of Science.
- Filippova, G. G. (2015). Prenatal stress: Enhanced risk in current pregnancy management and infertility treatment technologies. In VI-th International Scientific Conference "Psychological Problems of Modern Family" (pp. 418–426). Moscow-Zvenigorod.
- Chernenkova, Yu. V. (2014). Assessment of health indicators in children born using reproductive technologies. Saratov Scientific Medical Journal, 10(4), 683–688.
- Argyraki, M., Damdimopoulou, P., Chatzimeletiou, K., et al. (2019). In-utero stress and mode of conception: impact on regulation of imprinted genes, fetal development and future health. Human Reproduction Update, 25(6), 777–801. https://doi.org/10.1093/humupd/dmz025
- Barbuscia, A., & Mills, M. C. (2017). Cognitive development in children up to age 11 years born after ART: a longitudinal cohort study. Human Reproduction, 32(7), 1482–1488. https://doi.org/10.1093/humrep/dex102
- Bergh, C., & Wennerholm, U.-B. (2020). Long-term health of children conceived after assisted reproductive technology. Upsala Journal of Medical Sciences, 125(2), 152–157. https://doi.org/10.1080/03009734.2020.1729904
- Berntsen, S., Söderström-Anttila, V., Wennerholm, U.-B., Laivuori, H., Loft, A., Oldereid, N. B., et al. (2019). The health of children conceived by ART: 'The chicken or the egg?' Human Reproduction Update, 25(2), 137–158. https://doi.org/10.1093/humupd/dmz001
- Bokhan, T. G., Terekhina, O. V., Shabalovskaya, M. V., Silaeva, A. V., Leshchinskaia, S. B., Gayfulina, Zh. F., Aparina, K. V., Malykh, S. B., & Kovas, Yu. V. (2023). A study of correlations between newborn children outcomes and emotional states and attachment to a fetus in women pregnant using in-vitro fertilization. Journal of the Higher School of Economics, 20(3), 563–587. https://doi.org/10.17323/1813-8918-2023-3-563-587
- Chmel, R. Jr. (2020). Assisted reproductive methods – current status and perspectives. Ceska Gynekol, 85(4), 244–253.
- Cortese, M., Moster, D., & Wilcox, A. (2021). Term birth weight and neurodevelopmental outcomes. Epidemiology, 32(4), 583–590. https://doi.org/10.1097/EDE.0000000000001350
- Cozzani, M., Aradhya, S., & Goisis, A. (2021). The cognitive development from childhood to adolescence of low birthweight children born after medically assisted reproduction: a UK longitudinal cohort study. International Journal of Epidemiology, 50(5), 1514–1523. https://doi.org/10.1093/ije/dyab009
- Dehghan, M., Kuhi, M., & Rezvani, S. (2020). Speech and language development of children born following assisted reproductive technologies. International Journal of Pediatric Otorhinolaryngology, 134, 110060. https://doi.org/10.1016/j.ijporl.2020.110060
- Dokuhaki, S., & Dokuhaki, F. (2021). The relationship of maternal anxiety, positive and negative affect schedule, and fatigue with neonatal psychological health upon childbirth. Contraception and Reproductive Medicine, 6, 1–10. https://doi.org/10.1186/s40834-021-00155-8
- Dokuhaki, S., Heidary, M., & Akbarzadeh, M. (2019). The investigation of the effect of training attachment behaviors to pregnant mothers on some physical indicators of their infants from birth to three months based on the separation of male and female infant. Pediatrics & Neonatology, 60(3), 324–331. https://doi.org/10.1016/j.pedneo.2018.08.002
- Eastwood, J., Ogbo, F. A., & Hendry, A. (2017). The impact of antenatal depression on perinatal outcomes in Australian women. PLoS ONE, 12(1), e0169907. https://doi.org/10.1371/journal.pone.0169907
- Fauser, B. C., Devroey, P., Diedrich, K., Balaban, B., Bonduelle, M., et al. (2014). Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature. Reproductive Biomedicine Online, 28(2), 162–182. https://doi.org/10.1016/j.rbmo.2013.10.013
- Hansen, M., Greenop, K. R., Bourke, J., et al. (2018). Intellectual disability in children conceived using assisted reproductive technology. Pediatrics, 142(6), e20181269. https://doi.org/10.1542/peds.2018-1269
- Hart, R., & Norman, R. J. (2013). The longer-term health outcomes for children born as a result of IVF treatment: Part I – General health outcomes. Human Reproduction Update, 19(3), 232–243. https://doi.org/10.1093/humupd/dms062
- Hart, R., & Norman, R. J. (2013). The longer-term health outcomes for children born as a result of IVF treatment: Part II – Mental health and development outcomes. Human Reproduction Update, 19(3), 244–250. https://doi.org/10.1093/humupd/dmt002
- Heijligers, M., Verheijden, L. M. M., Jonkman, L. M., Van der Sangen, M., Meijer-Hoogeveen, M., Arens, Y., Van der Hoeven, M. A., & De Die-Smulders, C. E. M. (2018). The cognitive and socio-emotional development of 5-year-old children born after PGD. Human Reproduction, 33(11), 2150–2157. https://doi.org/10.1093/humrep/dey302
- Huang, X., & Fu, J. (2021). Association between assisted reproductive technology and white matter injury in premature infants: a case-control study. Frontiers in Pediatrics, 9, 686670. https://doi.org/10.3389/fped.2021.686670
- Hvidtjørn, D., Grove, J., Schendel, D., Schieve, L. A., Sværke, C., Ernst, E., & Thorsen, P. (2011). Risk of autism spectrum disorders in children born after assisted conception: a population-based follow-up study. Journal of Epidemiology and Community Health, 65(6), 497–502. https://doi.org/10.1136/jech.2009.093823
- Kocherova, O. Ju., Pykhtina, L. A., Gadzhimuradova, H. D., Filkina, O. M., & Malyshkina, A. I. (2016). Psychological characteristics of mothers of children conceived with the use of in vitro fertilization. Clinical Psychology and Special Education, (5), 69–77. https://doi.org/10.17759/psyclin.2016050305
- Lang, J., Zhang, B., Meng, Y., et al. (2019). First-trimester depression and/or anxiety disorders increase the risk of low birthweight in IVF offspring: a prospective cohort study. Reproductive BioMedicine Online, 39(6), 947–954. https://doi.org/10.1016/j.rbmo.2019.09.002
- Lazaraviciute, G., Kauser, M., Bhattacharya, S., et al. (2014). A systematic review and meta-analysis of DNA methylation levels and imprinting disorders in children conceived by IVF/ICSI compared with children conceived spontaneously. Human Reproduction Update, 20(6), 840–852. https://doi.org/10.1093/humupd/dmu033
- Maddahi, M. S., Dolatian, M., Khoramabadi, M., & Talebi, A. (2016). Correlation of maternal-fetal attachment and health practices during pregnancy with neonatal outcomes. Electronic Physician, 8(7), 2639–2644. https://doi.org/10.19082/2639
- McMahon, C. A., Boivin, J., Gibson, F. L., et al. (2013). Pregnancy-specific anxiety, ART conception and infant temperament at 4 months post-partum. Human Reproduction, 28(4), 997–1005. https://doi.org/10.1093/humrep/det029
- Pontesilli, M., Painter, R. C., Grooten, I. J., et al. (2015). Subfertility and assisted reproduction techniques are associated with poorer cardio-metabolic profiles in childhood. Reproductive Biomedicine Online, 30(3), 258–267. https://doi.org/10.1016/j.rbmo.2014.11.006
- Remes, H., Palma Carvajal, M., Peltonen, R., Martikainen, P., & Goisis, A. (2022). The well-being of adolescents conceived through medically assisted reproduction: a population-level and within-family analysis. European Journal of Population, 38(5), 915–949. https://doi.org/10.1007/s10680-022-09623-6
- Rice, F., Harold, G. T., Boivin, J., et al. (2010). The links between prenatal stress and offspring development and psychopathology: disentangling environmental and inherited influences. Psychological Medicine, 40(2), 335–345. https://doi.org/10.1017/S0033291709005911
- Roychoudhury, S., Lodha, A., Synnes, A., et al. (2021). Neurodevelopmental outcomes of preterm infants conceived by assisted reproductive technology. American Journal of Obstetrics and Gynecology, 225(3), 276.e1–276.e9. https://doi.org/10.1016/j.ajog.2021.03.027
- Rumbold, A. R., Moore, V. M., Whitrow, M. J., Oswald, T. K., Moran, L. J., Fernandez, R. C., et al. (2017). The impact of specific fertility treatments on cognitive development in childhood and adolescence: a systematic review. Human Reproduction, 32(7), 1489–1507. https://doi.org/10.1093/humrep/dex085
- Rumbold, A. R., Sevoyan, A., Oswald, T. K., et al. (2019). Impact of male factor infertility on offspring health and development. Fertility and Sterility, 111(6), 1047–1053. https://doi.org/10.1016/j.fertnstert.2019.05.006
- Sadowska, M., Sarecka-Hujar, B., & Kopyta, I. (2020). Cerebral palsy: current opinions on definition, epidemiology, risk factors, classification and treatment options. Neuropsychiatric Disease and Treatment, 16, 1505–1518. https://doi.org/10.2147/NDT.S235165
- Schendelaar, P., La Bastide-Van Gemert, S., Heineman, M. J., et al. (2016). Subfertility factors rather than assisted conception factors affect cognitive and behavioral development of 4-year-old singletons. Reproductive Biomedicine Online, 33, 752–762. https://doi.org/10.1016/j.rbmo.2016.08.021
- Skalny, A. V. (2018). Toxicological and nutritional status of trace elements in hair of women with in vitro fertilization (IVF) pregnancy and their 9-month-old children. Reproductive Toxicology, 82, 50–56. https://doi.org/10.1016/j.reprotox.2018.10.004
- Strömberg, B., Dahlquist, G., Ericson, A., et al. (2002). Neurological sequelae in children born after in-vitro fertilization: a population-based study. Lancet, 359(9305), 461–465. https://doi.org/10.1016/S0140-6736(02)07674-2
- Watanabe, C. (2017). Impact of essential trace elements on child growth and development. Japanese Journal of Health and Human Ecology, 83(6), 184–190. https://doi.org/10.3861/kenko.83.6_184
- Wilson, C. L., Fisher, J. R., Hammarberg, K., Amor, D. J., & Halliday, J. L. (2011). Looking downstream: a review of the literature on physical and psychosocial health outcomes in adolescents and young adults who were conceived by ART. Human Reproduction, 26(5), 1209–1219. https://doi.org/10.1093/humrep/der041
- Xing, L. F., Qu, F., Qian, Y. L., Zhang, F. H., Zhu, Y. M., & Xu, X. F. (2011). The social adaptation of children born after ICSI compared with IVF-conceived children: a study from China. Journal of Obstetrics and Gynaecology, 31(8), 751–753. https://doi.org/10.3109/01443615.2011.606937
- Xu, G. F., Zhou, C. L., Xiong, Y. M., et al. (2017). Reduced intellectual ability in offspring of ovarian hyperstimulation syndrome: a cohort study. EBioMedicine, 20, 263–267. https://doi.org/10.1016/j.ebiom.2017.05.020
Supplementary files
