Etiopathogenesis of post-COVID syndrome

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Abstract

Background. A significant number of people around the world have been affected by the SARS-CoV-2 virus, and the complex of symptoms known as post-COVID syndrome is also widespread after full recovery from COVID-19. Due to the lack of comprehensive research on the etiology and pathogenesis of post-COVID syndrome, it is essential to analyze relevant scientific publications in order to systematically review available data and develop a strategy for future studies.

Purpose. Based on the analysis of data published in contemporary medical scientific literature, our aim was to systematize information about the etiology and pathogenesis of post-COVID syndrome, one of the leading causes of early complications following surgical treatment.

Materials and methods. The review included foreign and domestic studies published over the past 10 years, selected using the keywords from bibliographic databases such as PubMed, Cyberleninka, and Elibrary.

Results. The analysis of data aimed at understanding the mechanisms of post-COVID syndrome has been completed. Post-COVID syndrome is a set of pathophysiological processes that occur during the acute phase of the illness and after its main symptoms have subsided.

Conclusion. SARS-CoV-2 infection has an overall and local immunosuppressive, neurotoxic, and antiviral effect, leading to the development of postoperative complications. Data on the pathophysiological mechanisms that develops both during SARS-CoV-2 disease and after the main symptoms has subsided can be used to develop preventive measures for postoperative complications.

About the authors

Sergey G. Bezrukov

V.I. Vernadsky Crimean Federal University

Author for correspondence.
Email: ph.bezrukov@gmail.com

MD, Professor, Head of the Department of Surgical Dentistry and Maxillofacial Surgery

 

Russian Federation, 4, Vernadsky Ave., Simferopol, 295007, Russian Federation

Kirill O. Tarimow

V.I. Vernadsky Crimean Federal University

Email: kirito.k@yandex.ru

Postgraduate Student, Department of Surgical Dentistry and Maxillofacial Surgery

 

Russian Federation, 4, Vernadsky Ave., Simferopol, 295007, Russian Federation

Vladimir Z. Kharchenko

V.I. Vernadsky Crimean Federal University

Email: julianashramko@rambler.ru

Doctor of Biological Sciences, Professor of the Department of General and Clinical Pathophysiology

 

Russian Federation, 4, Vernadsky Ave., Simferopol, 295007, Russian Federation

Aider A. Ibraimov

V.I. Vernadsky Crimean Federal University

Email: rediarey@bk.ru

Student, Department of General and Clinical Pathophysiology

 

Russian Federation, 4, Vernadsky Ave., Simferopol, 295007, Russian Federation

Aziz Z. Seityagyaev

V.I. Vernadsky Crimean Federal University

Email: seityagyayev.aziz@bk.ru

Student, Department of General and Clinical Pathophysiology

 

Russian Federation, 4, Vernadsky Ave., Simferopol, 295007, Russian Federation

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