Regression of chronic pain syndrome refractory to opioid pharmacotherapy in a patient after implantation of a spinal cord neurostimulator: case report
- Authors: Burmistrova A.V.1, Vorobyev A.N.1, Varyukhina M.D.1, Ilina A.A.1,2, Radutnaya M.L.1, Yakovlev A.A.1, Grechko A.V.1
-
Affiliations:
- Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
- Peoples’ Friendship University of Russia
- Issue: Vol 4, No 4 (2022)
- Pages: 283-291
- Section: CASE REPORT
- URL: https://journal-vniispk.ru/2658-6843/article/view/232722
- DOI: https://doi.org/10.36425/rehab111062
- ID: 232722
Cite item
Full Text
Abstract
BACKGROUND: Pain in cancer patients, often poorly treated, cause severe distress for patients and their caregivers, and significantly reduces quality of life. Modern guides for the medical treatment of chronic pain in cancer patients are not effective in all cases, especially when chronic neuropathic pain syndrome occurs. In this regard, there is a need for a multidisciplinary personalized approach to the tactics of chronic pain management in favor of surgical methods at earlier stages of this condition. Nowadays neuromodulation is widely used for the treatment of neuropathic chronic pain syndrome in patients with various pathologies, whereas it is not used routinely in cancer patients.
CLINICAL CASE DESCRIPTION: We introduce a case report of successfully applied neuromodulation in patient with severe chronic pain syndrome due to rectal cancer. Epidural spinal cord stimulation at Th10–Th12 levels allowed to stop the systemic use of opioids and achieve long-term remission. Spinal cord stimulation has shown itself to be very promising and significantly improved patient’s quality of life.
CONCLUSIONS: Our case report evidently shows that current chronic pain management guides and treatment recommendations needs a revision and neuromodulation usage in category of cancer patients should be considered.
Full Text
##article.viewOnOriginalSite##About the authors
Aleksandra V. Burmistrova
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
Author for correspondence.
Email: aburmistrova@fnkcrr.ru
ORCID iD: 0000-0001-5532-5396
SPIN-code: 4477-8293
врач-нейрохирург
Russian Federation, MoscowAlexey N. Vorobyev
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
Email: avorobyev@fnkcrr.ru
ORCID iD: 0000-0003-3742-6171
SPIN-code: 3253-7996
Russian Federation, Moscow
Maria D. Varyukhina
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
Email: mvaryuhina@fnkcrr.ru
ORCID iD: 0000-0001-8870-7649
SPIN-code: 7463-4645
Russian Federation, Moscow
Anna A. Ilina
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology; Peoples’ Friendship University of Russia
Email: shishova-1992@mail.ru
ORCID iD: 0000-0001-6188-870X
SPIN-code: 1200-3966
Russian Federation, Moscow; Moscow
Margarita L. Radutnaya
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
Email: mradutnaya@fnkcrr.ru
ORCID iD: 0000-0002-9181-2295
SPIN-code: 1077-5970
Russian Federation, Moscow
Alexey A. Yakovlev
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
Email: ayakovlev@fnkcrr.ru
ORCID iD: 0000-0002-8482-1249
SPIN-code: 2783-9692
MD, Cand. Sci. (Med.)
Russian Federation, MoscowAndrey V. Grechko
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
Email: avgrechko@fnkcrr.ru
ORCID iD: 0000-0003-3318-796X
SPIN-code: 4865-8723
MD, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences
Russian Federation, MoscowReferences
- WHO’s pain relief ladder for cancer pain relief. Annex 2 [Internet]. In: World Health Organization. Cancer pain relief. Geneva; 1986. Р. 71–74. Available from: https://apps.who.int/iris/bitstream/handle/10665/43944/9241561009_eng.pdf. Accessed: 14.09.2022.
- Kogonia LM, Novikov GA, Orlova RV, et al. Practical recommendations for the treatment of chronic pain syndrome in adult cancer patients. Malignant Tumors. 2021;11(3):167–186. (In Russ). doi: 10.18027/2224-5057-2021-11-3s2-49
- Caraceni A, Shkodra M. Cancer pain assessment and classification. Cancers. 2019;11(4):510. doi: 10.3390/cancers11040510
- Scholz J, Finnerup NB, Attal N, еt al. The IASP classification of chronic pain for ICD-11: Chronic neuropathic pain. Pain. 2019;160(1):53–59. doi: 10.1097/j.pain.0000000000001365
- Malignant neoplasms in Russia in 2020 (morbidity and mortality). Statistical collection. Ed. by A.D. Kaprin, V.V. Starinsky, A.O. Shakhzadova. Moscow: Moskovskii nauchno-issledovatel’skii onkologicheskii institut imeni P.A. Gertsena; 2021. 252 р. (In Russ).
- World Health Organization, European Health Information Portal [Internet]. The incidence of cancer per 10,000 population. (In Russ). Available from: https://gateway.euro.who.int/ru/indicators/hfa_357-2320-incidence-of-cancer-per-100-000/visualizations/#id=19288. Accessed: 12.09.2022.
- Kogonia LM, Voloshin AG, Novikov GA, Sidorov AV. Practical recommendations for the treatment of chronic pain syndrome in cancer patients. Malignant Tumors. 2019;9(3):685–703. (In Russ). doi: 10.18027/2224-5057-2019-9-3s2-685-703
- Blasco MA. Chronic pain management in head and neck oncology. Otolaryngol Clin North Am. 2020;53(5):865–875. doi: 10.1016/j.otc.2020.05.015
- International Neuromodulation Society. Neuromodulation, or Neuromodulatory Effect [Internet]. Available from: https://www.neuromodulation.com/neuromodulation-defined. Accessed: 12.09.2022.
- Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965;150(3699):971–979. doi: 10.1126/science.150.3699.971
- Hofmeister M, Memedovich A, Brown S, еt al. Effectiveness of neurostimulation technologies for the management of chronic pain: a systematic review. Neuromodulation. 2020;23(2):150–157. doi: 10.1111/ner.13020
Supplementary files
