SYNTHESIS OF 1-[ω-(BROMOPHENOXY)ALKYL]-3-NAPHTHALENYLMETHYL DERIVATIVES OF URACIL AND THEIR ANALOGUES AS PROBABLE INHIBITORS OF HUMAN CYTOMEGALOVIRUS REPLICATION

Capa

Citar

Texto integral

Resumo

A new series of 1-[ω-(bromophenoxy) has been synthesizedalkyl]-uracil derivatives containing naphthalene-1-yl-, naphthalene-2-yl-, 1-brominaphthalene-2-ilmethyl, benzyl and anthracene-9-ilmethyl fragments in position 3 of uracil. Antiviral properties of synthesized compounds against human cytomegalovirus were studied. It was found that the compound, which has a bridge consisting of five methylene groups, has high anti-cytomegalovirus activity in vitro. uracil

Sobre autores

M. Paramonova

Volgograd State Medical University

Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd

E. Gureeva

Volgograd State Medical University

Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd

A. Ozerova

Volgograd State Medical University

Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd

R. Snoeck

Rega Institute for Medical Research, KU Leuven

Email: khandazhinskaya@bk.ru
Belgium, B-3000, Leuven, Herestraat 49 bus 1043

G. Andrei

Rega Institute for Medical Research, KU Leuven

Email: khandazhinskaya@bk.ru
Belgium, B-3000, Leuven, Herestraat 49 bus 1043

D. Alexandrov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Email: khandazhinskaya@bk.ru
Russian Federation, Moscow

A. Khandazhinskaya

V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences

Autor responsável pela correspondência
Email: khandazhinskaya@bk.ru
Russian Federation, Moscow

M. Novikova

Volgograd State Medical University

Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd

S. Kochetkov

V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences

Email: khandazhinskaya@bk.ru
Russian Federation, Moscow

Bibliografia

  1. Rodríguez-Goncer I., Fernández-Ruiz M., Aguado J.M. // Expert Rev. Anti. Infect. Ther. 2020. V. 18. P. 113–125.
  2. Karrer U., Mekker A., Wanke K., Tchang V., Haeberli L. // Exp. Gerontol. 2009. V. 44. P. 689–694.
  3. Jentzer A., Veyrard P., Roblin X., Saint-Sardos P., Rochereau N., Paul S., Bourlet T., Pozzetto B., Pillet S. // Microorganisms. 2020. V. 8. P. 1078.
  4. Richardson A.K., Walker L.C., Cox B., Rollag H., Ro-binson B.A., Morrin H., Pearson J.F., Potter J.D., Pater-son M., Surcel H.M., Pukkala E., Currie M.J. // Clin. Transl. Oncol. 2020. V. 22. P. 585–602.
  5. Lv Y.L., Han F.F., An Z.L., Jia Y., Xuan L.L., Gong L.L., Zhang W., Ren L.L., Yang S., Liu H., Liu L.H. // Intervirology. 2020. V. 63. P. 10–16.
  6. Plotkin S.A., Boppana S.B. // Vaccine. 2019. V. 37. P. 7437–7442.
  7. Permar S.R., Schleiss M.R., Plotkin S.A. // J. Virol. 2018. V. 92. P. e00030–18.
  8. Kotton C.N. // Curr Opin Organ Transplant. 2019. V. 24. P. 469–475.
  9. Sellar R.S., Peggs K.S. // Expert Opin. Biol. Ther. 2012. V. 12. P. 1161–1172.
  10. Faure E., Galperine T., Cannesson O., Alain S., Gnemmi V., Goeminne C., Dewilde A., Béné J., Lasri M., Lessore de Sainte Foy C., Lionet A. // Medicine. 2016. V. 95. P. e5226.
  11. Tan B.H. // Options Infect. Dis. 2014. V. 6. P. 256–270.
  12. El Helou G., Razonable R.R. // Infect. Drug Resist. 2019. V. 12. P. 1481–1491.
  13. Papanicolaou G.A., Silveira F.P., Langston A.A., Perei-ra M.R., Avery R.K., Uknis M., Wijatyk A., Wu J., Boeckh M., Marty F.M., Villano S. // Clin. Infect. Dis. 2019. V. 68. P. 1255–1264.
  14. Piret J., Boivin G. // Antiviral Res. 2019. V. 163. P. 91–105.
  15. Novikov M.S., Babkov D.A., Paramonova M.P., Khandazhinskaya A.L., Ozerov A.A., Chizhov A.O., Andrei G., Snoeck R., Balzarini J., Seley-Radtke K.L. // Bioorg. Med. Chem. 2013. V. 21. P. 4151–4157.
  16. Babkov D.A., Khandazhinskaya A.L., Chizhov A.O., Andrei G., Snoeck R., Seley-Radtke K.L., Novikov M.S. // Bioorg. Med. Chem. 2015. V. 23. P. 7035–7044.
  17. Maruyama T., Kozai S., Yamasaki T., Witvrouw M., Pannecouque C., Balzarini J., Snoeck R., Andrei G., De Clercq E. // Antivir. Chem. Chemother. 2003. V. 14. P. 271–279.
  18. Maruyama T., Demizu Y., Kozai S., Witvrouw M., Pannecouque C., Balzarini J., Snoecks R., Andrei G., De Clercq E. // Nucleosides Nucleotides Nucleic Acids. 2007. V. 26. P. 1553–1558.
  19. Novikov M.S., Valuev-Elliston V.T., Babkov D.A., Paramonova M.P., Ivanov A.V., Gavryushov S.A., Khandazhinskaya A.L., Kochetkov S.N., Pannecouque C., Andrei G., Snoeck R., Balzarini J., Seley-Radtke K.L. // Bioorg. Med. Chem. 2013. V. 21. P. 1150–1158.
  20. Paramonova M.P., Khandazhinskaya A.L., Ozerov A.A., Kochetkov S.N., Snoeck R., Andrei G., Novikov M.S. // Acta Naturae. 2020. V. 12. P. 134–139.
  21. Paramonova M.P., Snoeck R., Andrei G., Khandazhinskaya A.L., Novikov M.S. // Mendeleev Commun. 2020. V. 30. P. 602–603.
  22. Baker B.R., Kelley J.L. // J. Med. Chem. 1970. V. 13. P. 458–461.

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML
Baixar
2.

Baixar (73KB)
Metadados
3.

Baixar (46KB)
Metadados
4.

Baixar (47KB)
Metadados
5.

Baixar (42KB)
Metadados

Declaração de direitos autorais © М.П. Парамонова, Е.С. Гуреева, А.А. Озеров, R. Snoeck, G. Andrei, Д.А. Александров, А.Л. Хандажинская, М.С. Новиков, С.Н. Кочетков, 2023

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).