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Binary proton therapy of Ehrlich carcinoma using targeted gold nanoparticles
- Authors: Filimonova M.V.1,2, Kolmanovich D.D.3,4, Tikhonowski G.V.2, Petrunya D.S.4,2, Kotelnikova P.A.5, Shitova A.A.1, Soldatova O.V.1, Filimonov A.S.1, Rybachuk V.A.1, Kosachenko A.O.1, Nikolaev K.A.1, Demyashkin G.A.1, Popov A.A.2, Savinov M.S.2, Popov A.L.3,4, Zelepukin I.V.5, Lipengolts A.A.2,6, Shpakova K.E.2,6, Kabashin A.V.7, Koryakin S.N.1,2, Deyev S.M.5, Zavestovskaya I.N.4,2
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Affiliations:
- National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
- National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- P.N. Lebedev Physical Institute of the Russian Academy of Sciences
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Institution N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
- Aix-Marseille University
- Issue: Vol 516, No 1 (2024)
- Pages: 59-63
- Section: Articles
- URL: https://journal-vniispk.ru/2686-7389/article/view/263918
- DOI: https://doi.org/10.31857/S2686738924030104
- EDN: https://elibrary.ru/VTOKHA
- ID: 263918
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Abstract
Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro. Binary proton therapy using targeted Au-PEG-FA nanoparticles caused an 80% tumor growth inhibition effect in vivo. The use of targeted gold nanoparticles is promising for enhancing the proton irradiation effect on tumor cells and requires further research to increase the therapeutic index of the approach.
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About the authors
M. V. Filimonova
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre, Obninsk Institute for Nuclear Power Engineering
Russian Federation, Obninsk; ObninskD. D. Kolmanovich
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences; P.N. Lebedev Physical Institute of the Russian Academy of Sciences
Email: d.petrunya@lebedev.ru
Russian Federation, Pushchino; Moscow
G. V. Tikhonowski
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: d.petrunya@lebedev.ru
Russian Federation, Moscow
D. S. Petrunya
P.N. Lebedev Physical Institute of the Russian Academy of Sciences; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Author for correspondence.
Email: d.petrunya@lebedev.ru
Russian Federation, Moscow; Moscow
P. A. Kotelnikova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: d.petrunya@lebedev.ru
Russian Federation, Moscow
A. A. Shitova
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre
Russian Federation, ObninskO. V. Soldatova
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre
Russian Federation, ObninskA. S. Filimonov
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre
Russian Federation, ObninskV. A. Rybachuk
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre
Russian Federation, ObninskA. O. Kosachenko
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre
Russian Federation, ObninskK. A. Nikolaev
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre
Russian Federation, ObninskG. A. Demyashkin
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre
Russian Federation, ObninskA. A. Popov
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: d.petrunya@lebedev.ru
Russian Federation, Moscow
M. S. Savinov
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: d.petrunya@lebedev.ru
Russian Federation, Moscow
A. L. Popov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences; P.N. Lebedev Physical Institute of the Russian Academy of Sciences
Email: d.petrunya@lebedev.ru
Russian Federation, Pushchino; Moscow
I. V. Zelepukin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: d.petrunya@lebedev.ru
Russian Federation, Moscow
A. A. Lipengolts
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute); Institution N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
Russian Federation, Moscow; Moscow
K. E. Shpakova
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute); Institution N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Email: d.petrunya@lebedev.ru
Russian Federation, Moscow; Moscow
A. V. Kabashin
Aix-Marseille University
Email: d.petrunya@lebedev.ru
France, Marseille
S. N. Koryakin
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: d.petrunya@lebedev.ru
A. Tsyb Medical Radiological Research Centre, Obninsk Institute for Nuclear Power Engineering
Russian Federation, Obninsk; ObninskS. M. Deyev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: d.petrunya@lebedev.ru
Academician of the RAS
Russian Federation, MoscowI. N. Zavestovskaya
P.N. Lebedev Physical Institute of the Russian Academy of Sciences; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: d.petrunya@lebedev.ru
Russian Federation, Moscow; Moscow
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