MONOCATIONIC CHLORIN PHOTOSENSITIZER FOR EFFICIENT PHOTOINACTIVATION OF ANTIBIOTIC RESISTANT GRAM-NEGATIVE MICROORGANISMS

A. V. Kustov; Кустов А. В.; N. V. Kukushkina; Кукушкина Н. В.; E. V. Lyalyakina; Лялякина Е. В.; N. N. Solomonova; Соломонова Н. Н.; A. K. Gagua; Гагуа А. К.; O. I. Koifman; Койфман О. И.; D. B. Berezin; Березин Д. Б.

doi:10.31857/S2686953523700164

MONOCATIONIC CHLORIN PHOTOSENSITIZER FOR EFFICIENT PHOTOINACTIVATION OF ANTIBIOTIC RESISTANT GRAM-NEGATIVE MICROORGANISMS

Authors: Kustov A.V.¹, Kukushkina N.V.¹, Lyalyakina E.V.², Solomonova N.N.², Gagua A.K.³, Koifman O.I.¹^,4, Berezin D.B.⁴
Affiliations:
1. G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences (ISC RAS)
2. Ivanovo Regional Clinical Hospital
3. National Medical Research Center for Otorhinolaryngology of the Federal Medico-Biological Agency of Russia
4. Ivanovo State University of Chemistry and Technology
Issue: Vol 508, No 1 (2023)
Pages: 59-63
Section: CHEMISTRY
URL: https://journal-vniispk.ru/2686-9535/article/view/135964
DOI: https://doi.org/10.31857/S2686953523700164
EDN: https://elibrary.ru/EWDYHW
ID: 135964

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Abstract
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Abstract

We propose a monocationic chlorin photosensitizer for antimicrobial photodynamic therapy of superficial localized infections. The antimicrobial activity of this specie towards planktonic forms of nosocomial anti-biotic resistant pathogens, viz. Pseudomonas aeruginosa, Enterobacter cloacae и Acinetobacter baumannii was studied and compared with the activity of the well-established photosensitizer “Fotoran e₆”. Our results do indicate that monocationic chlorin provides efficient photoinactivation of all the three microorganisms and can be considered as a new agent for antimicrobial photodynamic therapy.

Keywords

antibiotic resistance microbial strains, antimicrobial photodynamic therapy, monocationic chlorin photosensitizer

References

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