电邮这篇文章 多骨型纤维异样增殖症： 一个有争议的病例的影像学结果
- 作者: De Michele F.1,2, Carpagnano F.A.1,2, Paparella M.T.1,2, Guglielmi G.1,2,3
-
隶属关系:
- Department of Clinical and Experimental Medicine, Foggia University School of Medicine
- Radiology Unit, Barletta University Campus UNIFG, “Dimiccoli” Hospital
- Radiology Unit, Hospital “Casa Sollievo Della Sofferenza”, San Giovanni Rotondo
- 期: 卷 3, 编号 1 (2022)
- 页面: 55-63
- 栏目: 临床病例及临床病例的系列
- URL: https://journal-vniispk.ru/DD/article/view/88605
- DOI: https://doi.org/10.17816/DD88605
- ID: 88605
如何引用文章
详细
纤维异样增殖症是一种罕见的肿瘤样良性先天性骨病，最可能与GNAS基因突变有关，临床表现范围广泛，从孤立的单骨和多骨形式至其他骨骼外表现（McCune-Albright综合征）。由于这些变化，骨脆性增加，骨折的风险更高。
本文描述了一名65岁的患者，她因主诉颈部和背部疼痛而入住我们的放射科。此前，该患者被诊断为颈部和胸部骨骼病变，疑似转移。在我科，该患者先前被诊断为纤维异样增殖症，随后通过X射线、计算机断层扫描和磁共振成像确认。最终诊断是基于骨活检的结果。
因此，纤维异样增殖症主要损坏骨骼，正常骨骼被发育不良的纤维组织取代。根据受影响骨骼的数量和相关的内分泌变化，可以区分三种形式的疾病：单骨、多骨和奥尔布赖特综合征。除其他外，鉴别诊断包括多发性骨髓瘤。选择了最佳治疗方法。
作者简介
Francesca De Michele
Department of Clinical and Experimental Medicine, Foggia University School of Medicine; Radiology Unit, Barletta University Campus UNIFG, “Dimiccoli” Hospital
Email: francesca.demichele82@gmail.com
ORCID iD: 0000-0002-6043-6362
意大利, Foggia; Foggia
Francesca A. Carpagnano
Department of Clinical and Experimental Medicine, Foggia University School of Medicine; Radiology Unit, Barletta University Campus UNIFG, “Dimiccoli” Hospital
Email: c.francesca1991@gmail.com
ORCID iD: 0000-0001-7681-2898
意大利, Foggia; Foggia
Maria T. Paparella
Department of Clinical and Experimental Medicine, Foggia University School of Medicine; Radiology Unit, Barletta University Campus UNIFG, “Dimiccoli” Hospital
Email: mt.paparella@gmail.com
ORCID iD: 0000-0003-2573-9509
意大利, Foggia; Foggia
Giuseppe Guglielmi
Department of Clinical and Experimental Medicine, Foggia University School of Medicine; Radiology Unit, Barletta University Campus UNIFG, “Dimiccoli” Hospital; Radiology Unit, Hospital “Casa Sollievo Della Sofferenza”, San Giovanni Rotondo
编辑信件的主要联系方式.
Email: giuseppe.guglielmi@unifg.it
ORCID iD: 0000-0002-4325-8330
Medical Doctor, Full Professor of Radiology, Department of Clinical and Experimental Medicine.
意大利, Foggia; Foggia; Foggia参考
- Neville BW, Damm DD, Allen CM, Bouquot JE. Bone pathology. In: Neville BW, Damm DD, Allen CM, Bouquot JE, editors. Oral and maxillofacial pathology. Philadelphia, PA: WB Saunders Company; 2002. Р. 553–557.
- Iseri PK, Efendi H, Demirci A, Komsuoglu S. Fibrous dysplasia of the cranial bones: a case report and review of the literature. Yale J Biol Med. 2005;78(3):141–145.
- Lustig LR, Holliday MJ, McCarthy FF, Nager GT. Fibrous dysplasia involving the skull base and temporal bone. Arch Otolaryngol Head Neck Surg. 2001;127(10):1239–1247. doi: 10.1001/archotol.127.10.1239
- Chapurlat RD, Orcel P. Fibrous dysplasia of bone and McCune-Albright syndrome. Best Pract Res Clin Rheumatol. 2008;22(1):55–69. doi: 10.1016/j.berh.2007.11.004
- Feller L, Wood N, Khammissa R, et al. The nature of fibrous dysplasia. Head Face Med. 2009;5:22. doi: 10.1186/1746-160X-5-22
- Riminucci M, Kuznetsov SA, Cherman N, et al. Osteoclastogenesis in fibrous dysplasia of bone: in situ and in vitro analysis of IL-6 expression. Bone. 2003;33(3):434–442. doi: 10.1016/s8756-3282(03)00064-4
- Kransdorf MJ, Moser RP, Gilkey FW. Fibrous dysplasia. Radiographics. 1990;10(3):519–537. doi: 10.1148/radiographics.10.3.2188311
- Bhattacharyya N, Wiench M, Dumitrescu C, et al. Mechanism of FGF23 processing in fibrous dysplasia. J Bone Miner Res. 2012;27(5):1132–1141. doi: 10.1002/jbmr.1546
- Yamamoto T, Imanishi Y, Kinoshita E, et al. The role of fibroblast growth factor 23 for hypophosphatemia and abnormal regulation of vitamin D metabolism in patients with McCune-Albright syndrome. J Bone MinerMetab. 2005;23(3):231–237. doi: 10.1007/s00774-004-0589-9
补充文件
