Email this article LIPOPOLYSACCHARIDE-INDUCED IMMUNOLOGICAL STRESS AT EARLY STAGES OF PREGNANCY AFFECTS THE DEVELOPMENT OF GONADOTROPIN RELEASING-HORMONE (GNRH)-PRODUCING SYSTEM
- Authors: Ignatiuk VM1, Izvolskaia MS1
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Affiliations:
- Koltzov Institute of Developmental Biology, Russian Academy of Science
- Issue: Vol 19, No 1S (2019)
- Pages: 24-26
- Section: Articles
- URL: https://journal-vniispk.ru/MAJ/article/view/19305
- ID: 19305
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Abstract
The aim of the present work was to study the development of afferent bonds between GnRH- and monoaminergic neurons in rat fetuses and to identify possible targets affected by LPS-induced inflammation. The innervation was analyzed using retrograde tracing method with DiI dye. At ED17 and ED21 olfactory bulbs (the area of GnRH migration) are innervated with monoaminergic neurons of septum and in lateral hypothalamus. The GnRH- and monoaminergic neuron interaction zones are sensitive to LPS (E. coli) prenatal exposure, which induces pro-inflammatory cytokine synthesis. We suppose that the olfactory bulbs of fetal forebrain can be a possible area of cytokine influence on GnRH- and monoaminergic neuron interaction.
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##article.viewOnOriginalSite##About the authors
V M Ignatiuk
Koltzov Institute of Developmental Biology, Russian Academy of Science
M S Izvolskaia
Koltzov Institute of Developmental Biology, Russian Academy of Science
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