Email this article BRAIN CELLS REACTION IN A RESPONSE TO ANTIGEN INJECTION IN ANIMALS EXPOSED TO ACUTE PRENATAL STRESS
- Authors: Shakleina PS1, Novikova NS1
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Affiliations:
- Institute of Experimental Medicine, Saint Petersburg
- Issue: Vol 19, No 1S (2019)
- Pages: 105-107
- Section: Articles
- URL: https://journal-vniispk.ru/MAJ/article/view/19350
- ID: 19350
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Abstract
Prenatal stress is one of the major cause of long-term disorders in behavioral and neuroimmunne processes. Emotional prenatal maternal stress (PRMS) performsin an offspring tendency to anxiety, depressive-like behavior and weakening memorizing skills. The study field was to determinate preproorexin gene expression of the maturity rats held in prenatal stress on the 19th day. The expression level was measured in two hours after intravenous LPS injection. qPCR shoved significant reduction in preproorexin gene expression in hypothalamus cells. This result corresponds with behavioral tests where animals exposed to stress during the late term of in utero development demonstrate less motion search activity which allovers to suspect a connection between prenatal stress and incidences of psycho-neuro-immunne relationships disorders.
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##article.viewOnOriginalSite##About the authors
P S Shakleina
Institute of Experimental Medicine, Saint Petersburg
N S Novikova
Institute of Experimental Medicine, Saint Petersburg
References
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