Email this article IMMUNE RESPONS OF CYTOKINES IN DIFFERENT COURSE OF VIRAL ENCEPHALITIS IN CHILDREN
- Authors: Skripchenko NV1, Ivanova GP1, Skripchenko EY.1, Zheleznikova GF1
-
Affiliations:
- Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia, Saint Petersburg
- Issue: Vol 19, No 1S (2019)
- Pages: 141-143
- Section: Articles
- URL: https://journal-vniispk.ru/MAJ/article/view/19368
- ID: 19368
Cite item
Full Text
Abstract
105 children aged 1-17 years with viral encephalitis (EF) were examined. Determined cytokines (TNF-α, IL-4, IL-10, IFN-α and IFN-γ) in serum and CSF. In acute course (n = 50) dominated (74%) Th1 type of immune response (IR) with a high average IFN-γ in the blood and CSF and IFN-γ / IL-4 = 8.3 and 11.9. With a prolonged flow (n = 25) - Th2 with indices IFN-γ / IL-4 = 0.75 and 0.79. In chronic (n = 30) - suppressive type of IR, in which the blood cytokines did not exceed the norm, and CSF were lower than in acute and prolonged course. Cytokines in acute and prolonged course of EF were higher in serum, and in chronic ~ 1.3-1.7 times higher in CSF than in blood, indicating their intrathecal synthesis in the long-term course of neu-roinfection. Types of IR and the intensity of cytokine synthesis were interrelated with the nature of the course of EF in children and the severity of infectious and cerebral symptoms.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
N V Skripchenko
Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia, Saint Petersburg
G P Ivanova
Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia, Saint Petersburg
E Yu Skripchenko
Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia, Saint Petersburg
G F Zheleznikova
Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia, Saint Petersburg
References
- Железникова Г.Ф., Cкрипченко Н.В., Иванова В.В., и др. Иммунология вирусных инфекций у детей // Современные подходы к диагностике, терапии и профилактике инфекционных заболеваний у детей: Научные труды. - СПб., 2012. - Т. 2. - С. 71-102.
- Скрипченко Е.Ю., Лобзин Ю.В., Пальчик А.Б., и др. Неврологические осложнения и прогноз их развития при ветряной оспе у детей // Педиатрия. Журнал им. Г.Н. Сперанского. - 2016. - Т. 95. - № 2. - С. 14-21.
- Скрипченко Е.Ю., Алексеева Л.А., Скрипченко Н.В., Бессонова Т.В. Сравнительная характеристика лабораторных показателей при энцефалите, диссеминированном энцефаломиелите и рассеянном склерозе у детей // Русский журнал детской неврологии. - 2018. - Т. 13. - № 3. - С. 25-35.
- Melissa Noacke, Pierre Miossec Th17 and regulatory T cell balance in autoimmune and inflommatory disease. Autoimmune reviews. 2014;13:668-677.
Supplementary files
