Email this article Normobaric intermittent postconditioning corrects development of anxiety-depressive state in the experimental model of post-traumatic stress disorder
- Authors: Zenko M.Y.1, Baranova K.A.1, Rybnikova E.A.1
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Affiliations:
- Pavlov Institute of Physiology of the Russian Academy of Sciences
- Issue: Vol 24, No 4 (2024)
- Pages: 51-59
- Section: Original research
- URL: https://journal-vniispk.ru/MAJ/article/view/284825
- DOI: https://doi.org/10.17816/MAJ636721
- ID: 284825
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Abstract
BACKGROUND: Despite the rapid increase in the prevalence of post-traumatic stress disorder, there are still no effective drugs for its treatment, therefore, the development of non-drug approaches is an extremely urgent task, which this study is aimed at solving.
AIM: To estimate experimentally the therapeutic effects of hypoxic postconditioning using intermittent normobaric hypoxia in a model of post-traumatic stress disorder-like pathology in rats.
MATERIALS AND METHODS: In the rat model of post-traumatic stress disorder “stress–restress”, the effects of three postconditioning regimes were investigated: three 5-min episodes of hypoxia with 9% oxygen interspaced with 15-min intervals of normoxia (reoxygenation) per day for 3 days after pathogenic stress (hypoxia/normoxia mode); three 5-min episodes of 9% hypoxia interspaced with 3-min intervals of hyperoxia with 30% oxygen in the mixture, per day for 3 days (hypoxia/hyperoxia mode); five 5-min episodes of 12% hypoxia and 3-min 30% O2 hyperoxia per day for 9 days (hypoxia/hyperoxia mode, prolonged). Animal behavior, hypothalamic-pituitary-adrenal axis function and indices of general blood analysis were analysed.
RESULTS: All the modes of normobaric postconditioning to a greater or lesser extent had a corrective effect on the manifestation of pathological symptomatology; however, triple hypoxia/hyperoxia postconditioning was more effective than other modes in terms of the totality of protective and absence of side effects.
CONCLUSIONS: The results suggest that postconditioning using intermittent normobaric hypoxia/hyperoxia for the treatment of anxiety-depressive disorders in humans, including post-traumatic stress disorder, may be a promising approach.
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##article.viewOnOriginalSite##About the authors
Mikhail Yu. Zenko
Pavlov Institute of Physiology of the Russian Academy of Sciences
Email: zenkomichail@mail.ru
ORCID iD: 0000-0002-9868-0598
SPIN-code: 6632-3116
Research Associate of the Laboratory of Regulation of Brain Neuron Functions
Russian Federation, 6 Makarova Emb., Saint Petersburg, 199034Ksenia A. Baranova
Pavlov Institute of Physiology of the Russian Academy of Sciences
Email: ksentippa@mail.ru
ORCID iD: 0000-0002-2746-2040
SPIN-code: 2648-7415
Cand. Sci. (Biology), Senior Research Associate of the Laboratory of Regulation of Brain Neuron Functions
Russian Federation, 6 Makarova Emb., Saint Petersburg, 199034Elena A. Rybnikova
Pavlov Institute of Physiology of the Russian Academy of Sciences
Author for correspondence.
Email: rybnikovaea@infran.ru
ORCID iD: 0000-0002-8956-726X
SPIN-code: 9663-4704
Dr. Sci. (Biology), Professor of RAS, Vice-director in science, Head of the Laboratory of Regulation of Brain Neuron Functions, Head of the Department of Physiology and Pathology of High Nervous Activity
Russian Federation, 6 Makarova Emb., Saint Petersburg, 199034References
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