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Post a Comment Synthesis and study of psychotropic activity spectrum of 4-aryl-2-benzoylmethylenehydrazono-4-oxobutanoic acids
- Authors: Pulina N.A.1, Krasnova A.I.1, Kuznetsov A.S.1, Naugolnykh E.A.1
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Affiliations:
- Perm State Pharmaceutical Academy
- Issue: Vol 39, No 4 (2022)
- Pages: 65-70
- Section: Clinical studies
- URL: https://journal-vniispk.ru/PMJ/article/view/110801
- DOI: https://doi.org/10.17816/pmj39465-70
- ID: 110801
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Abstract
Objective. To study psychotropic activity of 4-aryl-2-benzoylmethylenhidrazono-4-oxobutanoic acids, as well as to determine the relationship between the structure of substances and their biological activity.
Materials and methods. The spectrum of psychotropic activity of 4-aryl-2-benzoylmethylenehydrazono-4-oxobutanoic acids was studied on experimental animals using the open field, black-and-white camera, and extrapolation deliverance tests.
Results. Psychopharmacological effects of various severity and direction were revealed. Two compounds showed anxiogenic properties without deterioration in cognitive potential, one substance displayed a trend to anxiolytic activity. The effect of the certain radicals in the structure of the substances on the studied activities was found.
Conclusions. The obtained links between the structure of original compounds and their psychotropic action can be used in further targeted synthesis and search for new domestic pharmaceutical substances with investigated effects in a series of derivatives of 2,4-dioxobutanoic acids.
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##article.viewOnOriginalSite##About the authors
N. A. Pulina
Perm State Pharmaceutical Academy
Author for correspondence.
Email: pulina-nata@mail.ru
Doctor of Pharmaceutical Science, Professor, Head of Department of Pharmaceutical Technology
Russian Federation, PermA. I. Krasnova
Perm State Pharmaceutical Academy
Email: pulina-nata@mail.ru
Candidate of Pharmaceutical Science, Associate Professor, Department of Pharmacology
Russian Federation, PermA. S. Kuznetsov
Perm State Pharmaceutical Academy
Email: pulina-nata@mail.ru
Candidate of Pharmaceutical Sciences, Associate Professor, Department of General and Organic Chemistry
Russian Federation, PermE. A. Naugolnykh
Perm State Pharmaceutical Academy
Email: pulina-nata@mail.ru
Candidate of Philological Sciences, Associate Professor, Department of Foreign Languages
Russian Federation, PermReferences
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