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Post a Comment Immunogenetic parameters in children with atopic diseases
- Authors: Illek Y.Y.1, Suetina I.G.1, Khlebnikova N.V.1, Suslova E.V.1, Savinova M.V.2, Dudyreva E.V.2, Zemtsova E.V.2
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Affiliations:
- Kirov State Medical University
- Pediatric Clinical Consultative and Diagnostic Center
- Issue: Vol 40, No 1 (2023)
- Pages: 27-33
- Section: Original studies
- URL: https://journal-vniispk.ru/PMJ/article/view/144128
- DOI: https://doi.org/10.17816/pmj40127-33
- ID: 144128
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Abstract
Objective. To determine the features of the distribution of antigens of the major histocompatibility complex in children of preschool and primary school age with atopic diseases.
Materials and methods. Under observation there were children with a moderate course of the diseases such as atopic dermatitis, atopic dermatitis with concomitant persistent allergic rhinitis, independent persistent allergic rhinitis, atopic bronchial asthma. The patients were identified class I and class II antigens of HLA-complex.
Results. The studies have shown that patients with atopic dermatitis had a high incidence of HLA B15, DRB1*13 and DQB1*0602-8: in patients suffering from atopic dermatitis with concomitant persistent allergic rhinitis – HLA B12, B13 and DQB1 * 01; in patients with independent persistent allergic rhinitis – HLA A10 and DQB1 * 201; in patients with atopic bronchial asthma – HLA B18.
Conclusions. Representation of these antigens of the HLA complex in the tissues was associated with an increase in the risk of atopic diseases by 2.3–4.6 times.
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##article.viewOnOriginalSite##About the authors
Ya. Yu. Illek
Kirov State Medical University
Author for correspondence.
Email: yanillek@gmail.com
MD, PhD, Professor, Head of Department of Pediatrics
Russian Federation, KirovI. G. Suetina
Kirov State Medical University
Email: yanillek@gmail.com
Candidate of Medical Sciences, Associate Professor, Department of Pediatrics
Russian Federation, KirovN. V. Khlebnikova
Kirov State Medical University
Email: yanillek@gmail.com
Candidate of Medical Sciences, Associate Professor, Department of Pediatrics
Russian Federation, KirovE. V. Suslova
Kirov State Medical University
Email: yanillek@gmail.com
Candidate of Medical Sciences, Assistant, Department of Pediatrics
Russian Federation, KirovM. V. Savinova
Pediatric Clinical Consultative and Diagnostic Center
Email: yanillek@gmail.com
Chief Physician
Russian Federation, KirovE. V. Dudyreva
Pediatric Clinical Consultative and Diagnostic Center
Email: yanillek@gmail.com
Deputy Chief Physician
Russian Federation, KirovE. V. Zemtsova
Pediatric Clinical Consultative and Diagnostic Center
Email: yanillek@gmail.com
pediatrician, allergologist-immunologist
Russian Federation, KirovReferences
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