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Post a Comment Clinical and pathomorphological “masks” of adrenocortical cancer. Difficulties of differential diagnostics by the example of own clinical observa-tions
- Authors: Yashina D.P.1, Afanasyeva Z.A.1,2, Mazitova F.M.2, Sabirov A.G.2, Zhavoronkov A.E.1,2
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Affiliations:
- Kazan State Medical Academy
- Professor M.Z. Sigal Republican Clinical Oncological Dispensary
- Issue: Vol 40, No 5 (2023)
- Pages: 147-157
- Section: Clinical case
- URL: https://journal-vniispk.ru/PMJ/article/view/254818
- DOI: https://doi.org/10.17816/pmj405147-157
- ID: 254818
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Abstract
Difficulties in the differential diagnostics of adrenocortical cancer (ACC) are due to its heterogeneous clinical and biological behavior, which is based on a complex histogenesis and molecular genetic landscape of adrenocortical cells. In this connection, the “postulate” in the diagnosis and treatment of ACC should be a multidisciplinary approach in centers with experience in adrenal surgery and pathomorphology. The presented own clinical observations of patients with ACC diagnosed during a multiple revision of histological slides and repeated immunohistochemistry including recurrent tumor, illustrates the complexity of differential diagnosis and shows the need for further study of the subcellular mechanisms of adrenocortical oncogenesis underlying its clinical picture, morphology, and expression of valuable specific markers.
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##article.viewOnOriginalSite##About the authors
D. P. Yashina
Kazan State Medical Academy
Author for correspondence.
Email: darya.nikulina.94@list.ru
ORCID iD: 0000-0003-2746-8837
Postgraduate Student, Department of Oncology, Radiology and Palliative Medicine
Russian Federation, KazanZ. A. Afanasyeva
Kazan State Medical Academy; Professor M.Z. Sigal Republican Clinical Oncological Dispensary
Email: darya.nikulina.94@list.ru
ORCID iD: 0000-0002-6187-2983
MD, PhD, Professor of the Department of Oncology, Radiology and Palliative Medicine, Head of the Center for Diagnostics and Treatment of Patients with Thyroid and Other Endocrine Organs Tumors
Russian Federation, Kazan; KazanF. M. Mazitova
Professor M.Z. Sigal Republican Clinical Oncological Dispensary
Email: darya.nikulina.94@list.ru
Pathologist of the Pathologicoanatomic Department
Russian Federation, KazanA. G. Sabirov
Professor M.Z. Sigal Republican Clinical Oncological Dispensary
Email: darya.nikulina.94@list.ru
Candidate of Medical Sciences, pathologist, Head of the Pathologicoanatomic Department
Russian Federation, KazanA. E. Zhavoronkov
Kazan State Medical Academy; Professor M.Z. Sigal Republican Clinical Oncological Dispensary
Email: darya.nikulina.94@list.ru
Radiologist, Head of the PET Department, Assistant of the Department of Oncology, Radiology and Palliative Medicine
Russian Federation, Kazan; KazanReferences
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