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Post a Comment Prediction of fetal growth restriction in obese women
- Authors: Makarova E.L.1, Terekhina N.A.2, Padrul M.M.2
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Affiliations:
- M.A. Tverye City Clinical Hospital
- E.A. Vagner Perm State Medical University
- Issue: Vol 41, No 4 (2024)
- Pages: 80-86
- Section: Methods of diagnosis and technologies
- URL: https://journal-vniispk.ru/PMJ/article/view/267875
- DOI: https://doi.org/10.17816/pmj41480-86
- ID: 267875
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Abstract
Objective. To develop a way of prediction of fetal growth restriction in the first trimester of pregnancy in obese women.
Materials and methods. 85 obese pregnant women at 6–9 weeks of gestation took part in the study. Obesity was determined by body mass index, as squared height (m)-to-weight (kg) ratio, with a BMI > 30 kg/m2. In the blood serum of all patients the level of total copper (Cuvol.) was determined by the colorimetric method, and ceruloplasmin (CP) by of V.S. Kamyshnikov`s method and the percentage of free copper (Cufree) was calculated. The free copper index was calculated using the formula: Cufree = (Cuvol. – (ceruloplasmin · 3)) / Cuvol. · 100, where
Cufree is the percentage of free copper in the blood serum, %; Cuob. – content of total copper in blood serum, µmol/l; CP – content of ceruloplasmin in blood serum, mg/l; 3 – conversion factor. All pregnant women were divided into two groups depending on the percentage of free copper: group A – pregnant women with obesity and free copper content > 25 % (n = 26); group B – obese pregnant women with a percentage of free copper < 25 %, (n = 59). The control group consisted of 20 pregnant women with normal body weight.
Results. Among the studied groups, in pregnant women with obesity statistically significant differences in the content of total copper (p = 0.013), and the percentage of free copper (p = 0.041) were revealed. In the group of pregnant women with a free copper content > 25 % chronic placental insufficiency occurred 1.5 times more frequently and fetal growth restriction syndrome was 6.4 times more frequent than in the group of patients with a free copper content of < 25 %.
Conclusion. The free copper level, determined in the first trimester of pregnancy equal to 25% or more, can be considered as a predictor of fetal growth restriction in obese pregnant women.
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##article.viewOnOriginalSite##About the authors
E. L. Makarova
M.A. Tverye City Clinical Hospital
Author for correspondence.
Email: makarova_803@mail.ru
ORCID iD: 0000-0002-1330-8341
Degree Candidate of the Department of Obstetrics and Gynecology №1
Russian Federation, PermN. A. Terekhina
E.A. Vagner Perm State Medical University
Email: makarova_803@mail.ru
ORCID iD: 0000-0002-0168-3785
DSc (Medicine), Professor, Head of the Department of Biological Chemistry
Russian Federation, PermM. M. Padrul
E.A. Vagner Perm State Medical University
Email: makarova_803@mail.ru
ORCID iD: 0000-0002-6111-5093
DSc (Medicine), Professor, Head of the Department of Obstetrics and Gynecology № 1
Russian Federation, PermReferences
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