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Post a Comment Evaluation of effectiveness of thioctic acid use in combined therapy of angiodistonia and polyneuropathy syndrome
- Authors: Malyutina N.N.1, Bolotova A.F.1, Eremeev R.B.1, Sosnin D.Y.1
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Affiliations:
- E.A. Vagner Perm State Medical University
- Issue: Vol 37, No 4 (2020)
- Pages: 17-25
- Section: Original studies
- URL: https://journal-vniispk.ru/PMJ/article/view/42292
- DOI: https://doi.org/10.17816/pmj37417-25
- ID: 42292
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Abstract
Objective. The aim of the study was to investigate the effectiveness of the preparation of thioctic acid combined with standard therapy among patients with angiodistonic syndrome and vegetative-sensory polyneuropathy of the extremities due to the influence of general vibration.
Materials and methods. A prospective randomized study of two groups of patients with vibration disease was conducted: the main group (n = 30) and the comparison group (n = 30). All patients received standard therapy, while the main group received additional therapy with octolipen (300 mg per os 2 times a day).
Results. The results of questionnaires and objective examination of patients did not establish the occurrence of any side effects when including the drug in the therapy. The survey data proved statistically significant differences in the assessment of pain syndrome at rest and in the occurrence of night pains (p = 0.022). At the same time, when assessing the severity of paresthesia, no statistically significant difference was found between the groups (p = 0.5536). The therapy was accompanied by normalization of the antioxidant status (AOS) in both groups: in the main group, the median AOS increased by 1.342 times and in the comparison group – by 1.267 times. In the statistical evaluation, the inclusion of thioctic acid in the treatment was accompanied by a statistically significant increase in the AOS not only with the initial data (p < 0.00001), but also in comparison with the results of treatment of patients in the comparison group (p = 0.0387). The data from the reovasographic study also showed that the therapy was more effective with additional inclusion of thioctic acid drug to it.
Conclusions. Thus, the data obtained justify the feasibility and effectiveness of using thioctic acid preparation in the treatment of angiodistonia and polyneuropathy syndromes.
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##article.viewOnOriginalSite##About the authors
Natal'ja N. Malyutina
E.A. Vagner Perm State Medical University
Email: dr-malyutina@yandex.ru
ORCID iD: 0000-0003-0996-6189
SPIN-code: 9767-7035
MD, PhD, Professor, Head of Department of Faculty Therapy №2, Professional Pathology and Clinical Laboratory Diagnosis
Russian Federation, 26, Petropavlovskaya St., Perm, 614990Arina F. Bolotova
E.A. Vagner Perm State Medical University
Email: arinabolotova@yandex.ru
professional pathologist, Perm Center of Professional Pathology
Russian Federation, 26, Petropavlovskaya St., Perm, 614990Roman B. Eremeev
E.A. Vagner Perm State Medical University
Email: yeremeyev@bk.ru
ORCID iD: 0000-0003-0695-7340
SPIN-code: 1988-2786
Candidate of Medical Sciences, Associate Professor, Department of Faculty Therapy №2, Professional Pathology and Clinical Laboratory Diagnosis
Russian Federation, 26, Petropavlovskaya St., Perm, 614990Dmitriy Yu. Sosnin
E.A. Vagner Perm State Medical University
Author for correspondence.
Email: sosnin_dm@mail.ru
ORCID iD: 0000-0002-1232-8826
SPIN-code: 4204-6796
Scopus Author ID: 36020670100
MD, PhD, Professor, Department of Faculty Therapy №2, Professional Pathology and Clinical Laboratory Diagnosis
Russian Federation, 26, Petropavlovskaya St., Perm, 614990References
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