Studying of dynamics of Alzheimer's disease symptoms manifestation against the background of COVID-19 in department № 5 for treatment of COVID-19, city clinical hospital № 2 named after F.H. Gral

A clinical case was analyzed, the regularity and dynamics of psychoneurological symptoms was studied in a patient with a moderately severe form of the course of a new coronavirus infection with concomitant neurodegenerative disease – Alzheimer's disease.

The patient aged 73 was admitted to the City Clinical Hospital №2 named after F.H. Gral by the team of emergency care with identified COVID-19. When admitted to the hospital, she had disability group 2 regarding neurodegenerative disease – Alzheimer's disease. A multispiral computed tomography of the head revealed the following: internal open substitutional hydrocephalus, moderately expressed bilateral leukoaraiosis, cerebral atrophy, predominantly in temporoparietal region, that is typical for Alzheimer's disease.

The results of tests indicated a decrease in cognitive status. In the test with figures, the patient could not find the required figure for the desired time. When conducting “clock-drawing test” in dynamics, at the second attempt the patient needed about 7 minutes; a worse capability for drawing was noted; apraxia was observed. The result of the test “6CIT” at the second attempt, carried out before discharge from the hospital became worse – she could answer only one of four questions, whereas at the first attempt, when admitted, she could answer two questions of four. By the time of discharge from the hospital, the patient was noted to have more pronounced cognitive disorders than at admission. Emotional lability, nervousness and anxiety also remain.