Грелиновые механизмы пищевого вознаграждения. Часть 2. Взаимодействие грелина с гормонами, нейропептидами и другими эндогенными лигандами
- Авторы: Рейхардт Б.А.1, Шабанов П.Д.1
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Учреждения:
- Институт экспериментальной медицины
- Выпуск: Том 20, № 3 (2022)
- Страницы: 229-254
- Раздел: Научные обзоры
- URL: https://journal-vniispk.ru/RCF/article/view/112451
- DOI: https://doi.org/10.17816/RCF203229-254
- ID: 112451
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Аннотация
Гормон голода, грелин, вырабатывается не только в ответ на недостаток пищи, но и выделяется при различных видах стресса. В последние годы подъем уровня грелина стал рассматриваться как неотъемлемый компонент стресс-реакции. Обзор посвящен грелин-зависимым механизмам, обеспечивающим реципрокное взаимодействие между осью гипоталамус – гипофиз – кора надпочечников и дофаминергической системой вознаграждения. Рассматриваются прямые и обратные связи между стресс-реализующей системой паравентрикулярного ядра, нейросетями латерального гипоталамуса и дугообразного ядра (образующие центры голода/насыщения), и мезолимбической системой награды. Обсуждается роль периферических гормонов сытости и глюкокортикоидов в регуляции мотивации и подкрепления, а также участие эндогенных опиоидных и эндоканнабиноидных рецепторов в «обучении» дофаминергических нейронов вентральной области покрышки и гиппокампа.
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Борис Андреевич Рейхардт
Институт экспериментальной медицины
Автор, ответственный за переписку.
Email: reihardt@mail.ru
ORCID iD: 0000-0003-3371-9161
SPIN-код: 8980-1073
канд. мед. наук, старший научный сотрудник
Россия, 197376, Санкт-Петербург, ул. Академика Павлова, д. 12Петр Дмитриевич Шабанов
Институт экспериментальной медицины
Email: pdshabanov@mail.ru
ORCID iD: 0000-0003-1464-1127
SPIN-код: 8974-7477
д-р мед. наук, профессор, заведующий отделом
Россия, 197376, Санкт-Петербург, ул. Академика Павлова, д. 12Список литературы
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